7461-94-1

Usage

Uses

Used in Pharmaceutical Industry:
N-propylsalicylamide is used as an analgesic and anti-inflammatory agent for its ability to reduce pain and inflammation by interacting with specific receptors in the body.
Used in Topical Creams and Ointments:
N-propylsalicylamide is used as an active ingredient in topical creams and ointments for the treatment of muscle aches, joint pain, and other types of discomfort due to its analgesic and anti-inflammatory properties.
Used in Skincare and Cosmetic Products:
N-propylsalicylamide is being investigated for its potential use in the treatment of certain skin conditions and as an ingredient in cosmetic and skincare products, likely due to its anti-inflammatory effects and potential benefits for the skin.

Upstream product

• 107-10-8 propylamine 
• 1441-87-8 salicyloyl chloride 
• 118-55-8 phenyl Salicylate 
• 52942-40-2 3-propyl-3,4-dihydro-2H-1,3-benzoxazine-2,4-dione 
• 119-36-8 methyl salicylate 
• 69-72-7 salicylic acid 
• 10546-70-0 N-(n-propyl)benzamide 
• 61141-14-8 anionic phenyl salicylate 
• 100391-16-0 2-acetoxy-benzoic acid propylamide 

Downstream Products

• 121970-07-8 2-(tetra-O-acetyl-β-D-glucopyranosyloxy)-benzoic acid propylamide 
• 14990-77-3 2-β-D-galactopyranosyloxy-benzoic acid propylamide 
• 20973-05-1 3-propyl-2,3-dihydro-4H-benzo[e][1,3]oxazin-4-one 
• 20973-06-2 6-nitro-3-propyl-2,3-dihydro-benzo[e][1,3]oxazin-4-one 
• 84672-90-2 N-propyl-N-o-hydroxybenzylamine 
• 1268163-66-1 tert-butyl 2-hydroxybenzyl(propyl)carbamate 
• 1228879-00-2 2-((propylamino)methyl)phenol hydrochloride 
• 15062-20-1 2-β-D-glucopyranosyloxy-benzoic acid propylamide 

Relevant academic research and scientific papers

Compound and application of compound in preparation of medicines

The invention discloses a compound and its application in a medicine. the invention specifically provides a compound as shown in the formula (I) or a stereisomer, a geometrical isomer, a tautomer, a racemate, nitric oxide, hydrate, a solvate, a metabolite, pharmaceutically acceptable salts or a prodrug of the compound as shown in the formula (I). The invention also discloses an application of the compound in preparation of a medicine. The medicine is used in treating cancers.

Lipase-Catalyzed Solvent-Free Amidation of Phenolic Acids

A series of N-alkyl-substituted amides, based on various phenolic acids, have been synthesized by the condensation of equimolar amounts of phenolic acids with different alkyl amines in the presence of Candida antarctica lipase at 60-90 °C in 16-20 h. The reactions were carried out in a solvent-free system without the use of any activating agents. All the products were obtained in appreciable amounts and the yields for different compounds varied between 75.6% and 83.5%. The synthesized compounds were characterized using spectroscopy techniques, namely infrared and NMR (1H and 13C). GRAPHICAL ABSTRACT.

Broadening the catalyst and reaction scope of regio- and chemoselective C-H oxygenation: A convenient and scalable approach to 2-acylphenols by intriguing Rh(ii) and Ru(ii) catalysis

A unique Rh(ii) and Ru(ii) catalyzed C-H oxygenation of aryl ketones and other arenes has been developed for the facile synthesis of diverse functionalized phenols. The reaction demonstrates excellent reactivity, regio- and chemoselectivity, good functional group compatibility and high yields. The practicality of this method has been proved by gram-scale synthesis of a few different 2-acylphenols. Its utility has been well exemplified in further applications in heterocycle synthesis and direct modifications of drug Fenofibrate.

SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS

Provided are compositions and methods useful for modulation of signaling through the Toll- like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.

Effects of mixed H2O-CH3CN solvents on the Bronsted coefficient for the intramolecular general base-catalyzed cleavage of ionized phenyl salicylate in the presence of primary and secondary amines

Nucleophilic second-order rate constants, knms, for the reactions of several primary and secondary amines with ionized phenyl salicylate (PS-) show a nonlinear decrease with the increase in the content of CH3CN from 2 to ≤50% v/v in mixed aqueous solvent. The values of knms remain almost unchanged with the change in the content of CH3CN at >50% v/v. The nucleophilic reactivity of primary and secondary amines toward PS- reveal Bronsted plots of different Bronsted coefficients, βnuc, at a constant content of CH3CN in mixed aqueous solvents. The values of βnuc decrease from 0.4 to nearly 0 for primary amines and from 0.22 to 0.12 for secondary amines with the increase in CH3CN content from 2 to 70% v/v. The values of knms/kMeOHms (where kMeOHms represents the nucleophilic second-order rate constant for the reaction of MeOH with PS- in H2O-CH3CN solvents), obtained within 2-50% v/v CH3CN, fit to an empirical equation: log (knms/kMeOHms) = θ+λX where X is the % v/v content of CH3CN, and θ and λ are empirical constants. It has been shown empirically that both θ and λ are the function of Bronsted coefficient βlg. The values of λ are used to calculate βlg and these βlg values for all amines except Tris lie within -0.32 to -0.46. The effects of mixed water-acetonitrile solvents on pKa of leaving the group, phenol, and conjugate acid of amine nucleophile have been concluded to be the major source for the observed solvent effects on knms. The βlg for Tris is unusually very close to zero.

Solvent effect on intramolecular general base-catalysed aminolysis of ionized phenyl salicylate

The nucleophilic second-order rate constants (k1) for the reactions of ionized phenyl salicylate (PS-) with primary and secondary amines in 70percent (v/v) ethanol-water reveal Bronsted plots of slopes βnuc1 = 0.32 +/- 0.10 and βnuc2 = 0.22 +/- 0.02, respectively.Different Bronsted slopes obtained for the reactions of PS- with primary and secondary amines suggest the occurrence of different locations of the transition state in the critical rate-determining step.The change in water content from 99.2 to 70percent (v/v) in EtOH-H2O causes reduction in k1 by ca. 3-fold for all the amines studied.Ionization constants of all the protonated amines turn out to be larger in 70percent (v/v) EtOH-H2O than in pure water.

Intramolecular General Base Catalysis and the Rate-determining Step in the Nucleophilic Cleavage of Ionized Phenyl Salicylate with Primary and Secondary Amines

The nucleophilic second-order rate constants for the reactions of ionized phenyl salicylate (PS-) with primary and secondary amines have revealed Broensted plots of slopes βnuc1 = 0.52+/-0.06 and βnuc2 = 0.27+/-0.05, respectively.The suggested stepwise reaction mechanism involves the intramolecular proton transfer from cationic nitrogen to the anionic phenolic oxygen to form the monoanionic tetrahedral addition intermediate as the rate-determining step.The low value of βnuc2 is attributed to the extensive of proton transfer in the late transition state while the large value of βnuc1 is ascribed to the proton transfer in the early transition state of the rate-determining step.However, these low and high values of βnuc2 and βnuc1, respectively, are also compatible with the occurence of respective early and late transition states in the rate-determining step involving concerted intramolecular general base-catalysed nucleophilic attack at the carbonyl carbon of PS-.Significantly large positive deviations from Broensted plots have been observed for the reactivities of α-nucleophiles toward PS-.Monoprotonated ethane-1,2-diamine is ca. 20-fold more reactive than would be expected from its basicity, and this is attributed to the occurence of the intramolecular general acid catalysis.The reactions of PS- with hydroxylamine and N-methylhydroxylamine involve ca. >/=70 percent aminolysis and -.

Effects of Anionic Micelles on Intramolecular General Base-catalysed Aminolysis of Phenyl and Methyl Salicylates

The effect of micelles of sodium dodecyl sulphate (SDS) on aminolysis of ionized phenyl salicylate (PS-) and methyl salicylate (MS-) have been studied at 35 deg C.An increase in the total concentration of SDS (T) from 0.0 to 0.2 mol dm-3 results in a decrease in the observed nucleophilic second-order rate constants (kn) by a factor of ca. 3 for the reactions of PS- with propylamine and 1-aminopropan-2-ol.At high T, plots of observed pseudo-first-order rate constants (kobs versus total propylamine concentration (T) appear to exhibit smaller slopes at T -3 compared with those at T > 0.01 mol dm-3, while for 1-aminopropan-2-ol such deviations from linearity at T -3 could not be detected.These observations are attributed to the higher hydrophilicity of 1-aminopropan-2-ol compared with that of propylamine.The values of kn for hydrazinolysis of MS- are decreased ca. 1.7-fold and those for hydroxylaminolysis MS- are increased ca. 2-fold with an increase in T from 0.0 to 0.2 mol dm-3.The values of kn for methylaminolysis of MS- are independent of T within the limits 0.0-0.2 mol dm-3.Dimethylamine did not show any detectable nucleophilic reactivity toward MS- in the presence of 0.03 mol dm-3 SDS.This shows that the presence of SDS perhaps does not change the nucleophilic reaction mechanism of aminolysis of salicylate esters.The observed results of aminolysis of PS- and MS- are rationalized in the light of the proposal of a porous cluster micellar structure.

11a-Methano-TXA compounds

The present invention provides novel 11a-methano-TXA compounds and intermediates and processs for their preparation. Further provided are methods for using these novel TXA analogs as inhibitors of thromboxane synthetase, rendering these analogs useful for a variety of pharmacological purposes. These pharmacological uses include anti-inflammatory, anti-thromobitc, and anti-asthma indications.