84672-90-2

Usage

Main properties

1. Chemical formula: C10H15NO
2. Phenolic compound
3. Contains a propylamine group
4. Pharmaceutical intermediate
5. Potential applications in organic synthesis

Specific content

Propylamino derivative of phenol
Used in the synthesis of various drugs
Building block for medication production
Ingredient in personal care and cosmetic products
Requires careful handling and safety precautions due to potentially hazardous properties

Upstream product

• 107-10-8 propylamine 
• 90-02-8 salicylaldehyde 
• 119-36-8 methyl salicylate 
• 7461-94-1 2-hydroxy-N-propylbenzamide 
• 69-72-7 salicylic acid 
• 932-30-9 2-Hydroxybenzylamine 
• 32382-63-1 N-n-propylsalicylideneamine 
• 26753-12-8 o-dimethylaminomethylphenol methylammonium iodide 

Downstream Products

• 1268163-66-1 tert-butyl 2-hydroxybenzyl(propyl)carbamate 
• 1228879-00-2 2-((propylamino)methyl)phenol hydrochloride 
• 1585946-47-9 C₂₁H₂₂N₂OS 
• 33316-78-8 2-[(isopropyloxy)methyl]phenol 

Relevant academic research and scientific papers

Fluorometric sensing of Hg2+ ions in aqueous medium by nano-aggregates of a tripodal receptor

Two new tripodal receptors (1-2) have been synthesized and characterized by various spectroscopic techniques. The nano-aggregates of 1 and 2 (N1 and N2) have been prepared by a re-precipitation method in aqueous medium and have shown different photo-physi

Development of chemosensor for Sr2+ using organic nanoparticles: Application of sensor in product analysis for oral care

A new series of compounds has been developed for the recognition of metal ions and it was found that the position of substituent in the organic compound proved to be the deciding factor for the development of a chemosensor. Reprecipitation method was used

Synthesis and biological activity of some novel substituted quinazoline derivatives

A new series of 4-N-(substituted benzyl)-2-phenyl-N-propylquinazolines were synthesized. The structures of the synthesized compounds were confirmed by IR, 1H NMR, 13C NMR and mass spectral analysis. All the synthesized compounds were screened for their analgesic and anti-inflammatory activity. Among the synthesized compounds 5c, 5h and 5o exhibited significant analgesic activity at 60 and 90 minutes reading, while compounds 5g, 5k and 5l exhibited significant anti-inflammatory activity at 3rd and 4th hr reading.

Synthesis of polymers bearing 1,3-benzoxazine moiety in the side chains from poly(allylamine) and their crosslinking behaviors

A polymer bearing 1,3-benzoxazine moiety in the side chain was synthesized successfully from poly(allylamine) based on a stepwise strategy consisted of three steps: (1) treatment of poly(allylamine) with salicylaldehyde to convert the amino group in the s

SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS

Provided are compositions and methods useful for modulation of signaling through the Toll- like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.

Task-specific ionic liquids bearing 2-hydroxybenzylamine units: Synthesis and americium-extraction studies

The synthesis of two task-specific ionic liquids (TSILs) bearing 2-hydroxybenzylamine entities is described. These compounds are based on an imidazolium substructure onto which one hydrobenzylamine-complexing moiety is grafted. We have demonstrated that,

Selective mono-N-alkylation of 3-amino alcohols via chelation to 9-BBN

(Chemical Equation Presented) A method for selective mono-N-alkylation of amino alcohols is introduced. This method relies on formation of a stable chelate with 9-BBN, which serves in the dual roles of protecting and activating the amine group. Three prot

Alkylation of amino acids and glutathione in water by o-Quinone methide. Reactivity and selectivity

o-Quinone methide (1) has been produced in water both thermally and photochemically from (2-hydroxybenzyl)trimethylammonium iodide (2). Michael addition reactions of 1 to various amines, and sulfides, including amino acids and glutathione have been carried out, obtaining alkylated adducts (3-16) in fairly good to quantitative yields. The reaction rate and selectivity of 1 toward nitrogen and sulfur nucleophiles, in competition with the hydration reaction, have been investigated at different pH by laser flash photolysis technique. The observed reactivity spans 7 orders of magnitude on passing from water (kNu = 5.8 M-1 s-1) to the most reactive nucleophile (2.8 × 108 M-1 s-1, 2-mercaptoethanol under alkaline conditions). These are the first direct reaction rate measurements of nucleophilic addition to the parent o-quinone methide (1). Competition experiments provided strong kinetic support to the involvement of free 1 as an intermediate in both thermal and photochemical reactions. Furthermore, several alkylation adducts regenerate 1 either by heating (9, 10, 13, and 14) or by irradiation (9, 11-13, 16). Such a thermal and photochemical reversibility of the alkylation process opens a new perspective for the use and application of such adducts as o-QM molecular carriers.

SOME REACTIONS OF PHENOLIC MALEAMIC ACIDS RELEVANT TO CARBOXYPEPTIDASE CATALYSIS

In neutral aqueous acetonitrile, N-o-hydroxybenzyl-2,3-dimethylmaleamic acid is rapidly converted to N-o-hydroxybenzyl-2,3-dimethylmaleimide, while N-propyl-N-o-hydroxybenzyl-2,3-dimethylmaleamic acid is converted to dimethylmaleic anhydride; both reactions are catalyzed by the phenolic groups.