74610-77-8

Basic information

• Product Name: 1,3-Dioxane-4,6-dione, 5-(4-methoxyphenyl)-2,2-dimethyl-5-phenyl-
• CAS NO: 74610-77-8
• Molecular Formula: C19H18O5
• Molecular Weight: 326.349
• Mol File: 74610-77-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1,3-Dioxane-4,6-dione, 5-(4-methoxyphenyl)-2,2-dimethyl-5-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dioxane-4,6-dione, 5-(4-methoxyphenyl)-2,2-dimethyl-5-phenyl-(74610-77-8)
• EPA Substance Registry System: 1,3-Dioxane-4,6-dione, 5-(4-methoxyphenyl)-2,2-dimethyl-5-phenyl-(74610-77-8)

Safety Data

• Hazardous Substances Data: 74610-77-8(Hazardous Substances Data)

Upstream product

• 15231-78-4 2.2-dimethyl-5-phenyl-1,3-dioxane-4,6-dione 
• 18649-43-9 4-methoxyphenyllead(IV) triacetate 

Relevant articles and documents

The Chemistry of Aryllead(IV) Tricarboxylates. Reaction with Derivatives of Malonic Acid: New Routes to α-Aryl Carboxylic Acids and Arylated Barbituric Acid Derivatives

Derivatives of 2,2-dimethyl-1,3-dioxan-4,6-dione (Meldrum's acid) and the sodium salts of substituted malonic esters undergo electrophilic C-arylation in high yield with aryllead triacetates, thus providing new routes to α-arylalkanoic acids.Syntheses of the antiflammatory compound 2-(p-isobutylphenyl)propanoic acid (Ibuprofen) have been carried out to demonstrate the method.The arylation reaction has been extended to 5-ethylbarbituric acid and to barbituric acid itself, which affords the 5,5-diarylated derivatives in good yield.A study of the effect of some tertiary bases on the reaction of p-methoxyphenyllead triacetate with the 5-isopropyl derivative of Meldrum's acid has shown that replacement of pyridine by 2,2'-bipyridyl results in an increase in yield and reaction rate, while a further marked improvement occurs in the presence of 1,10-phenanthroline.