7463-93-6

Usage

Type of compound

Benzene derivative

Functional groups

Bromine (Br) and methoxy (-OCH3) groups

Position of functional groups

Bromine at 1st and 5th positions, methoxy at 2nd position, and methyl (-CH3) at 3rd position

Common use

Organic synthesis and as a reagent in various chemical reactions

Hazardous properties

Harmful if swallowed or comes into contact with skin

Respiratory system

Can cause irritation if inhaled

Environmental hazards

Considered to have environmental hazards

Precautions

Careful handling and disposal to prevent release into the environment

Versatility

Used in various industries due to its chemical properties

Upstream product

• 609-22-3 2,4-dibromo-6-methylphenol 
• 77-78-1 dimethyl sulfate 
• 607-99-8 2,4,6-tribromoanisole 
• 917-54-4 methyllithium 
• 95-48-7 ortho-cresol 

Downstream Products

• 860585-44-0 2,4-dibromo-6-methyl-3,5-dinitro-anisole 

Relevant academic research and scientific papers

5-Cyano-2,3-dihydrobenzofurans useful as herbicides

The invention provides herbicidally-active 2,3-dihydro-5-cyanobenzofurans of the formula: STR1 (wherein: R1 and R2 together represent =O or R1 represents hydrogen and R2 represents hydrogen, hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, alkylthiocarbonyloxy, halogen, isothiocyanato, amino, alkylamino, dialkylamino, arylamino, acylamino, alkoxycarbonylamino, alkylthiocarbonylamino, N-bonded heterocyclyl, cyano or alkylthio; R3 and R4 together represent alkylene or each represent hydrogen or alkyl; and R5, R6 and R7, which may be the same or different, each represent hydrogen, halogen, alkyl, alkoxy, acyl or cyano), processes for their preparation and herbicidal compositions containing them.

Reactions of Alkyl-lithium Compounds with Aryl Halides

Reation of methyl-lithium with tribromophenols and with other aryl polyhalides leads directly to bi- and tri-aryl products. para-Substituents (Y) of 2,6-dibromo-4-Y-phenols promote arylation of substrates by their own lithiation products as Y becomes more electron-withdrawing.An aryne epoxide is not an intermediate in these reactions. 2,4,6-Tribromo-Z-benzenes react to form coupling products when Z can co-ordinate to an introduced ortho-lithium atom or when Z can be directly lithiated.Dimeric aggregation of the organolithium intermediates occurs so as to favor coupling to halogenated substrates.Both polar (ionic) and free-radical pathways are involved.