607-99-8

Basic information

• Product Name: 2,4,6-TRIBROMOANISOLE
• Synonyms: 1,3,5-tribromo-2-methoxy-benzen;1,3,5-Tribromo-2-methoxybenzene;Anisole, 2,4,6-tribromo-;Methyl 2,4,6-tribromophenyl ether;AKOS 237-128;2,4,6-TRIBROMOMETHOXYBENZENE;2,4,6-TRIBROMO-1-METHOXYBENZENE;2,4,6-TRIBROMOANISOLE
• CAS NO: 607-99-8
• Molecular Formula: C₇H₅Br₃O
• Molecular Weight: 344.83
• Product Categories: Aromatics;Intermediates;Miscellaneous Reagents
• Mol File: 607-99-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 84-88 °C(lit.)
• Boiling Point: 297-299 °C(lit.)
• Flash Point: 121.5 °C
• Appearance: White to pale brown/Solid
• Density: 2.4910
• Vapor Pressure: 0.00231mmHg at 25°C
• Refractive Index: 1.5580 (estimate)
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Methanol
• BRN: 2210361
• CAS DataBase Reference: 2,4,6-TRIBROMOANISOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,6-TRIBROMOANISOLE(607-99-8)
• EPA Substance Registry System: 2,4,6-TRIBROMOANISOLE(607-99-8)

Safety Data

• Hazard Codes: Xi
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 607-99-8(Hazardous Substances Data)

Usage

Chemical Properties

Off-White to Pale Yellow Solid

Uses

Different sources of media describe the Uses of 607-99-8 differently. You can refer to the following data:
1. 2,4,6-Tribromoanisole is suitable reagent used for the determination of 2,4,6-tribromoanisole in packaging materials and food by an analytical method based on multipleion detection GC-MS.
2. 2,4,6-Tribromoanisole is haloanisole often present in wine. 2,4,6-Tribromoanisole is one of the main agent responsible for the musty odor in wine sample

General Description

2,4,6-Tribromoanisole has been reported to cause cork taint in wines and vortex assisted liquid-liquid microextraction (VALLME) method for its determination has been developed. It is a musty-smelling metabolite of fungicide 2,4,6-tribromophenol. Determination of 2,4,6-trichloroanisole in wine at low ngL-1 levels by gas chromatography-high-resolution mass spectrometry (GC-HRMS) method has been repoted.

InChI:InChI=1/C7H5Br3O/c1-11-7-5(9)2-4(8)3-6(7)10/h2-3H,1H3

Upstream product

• 21702-84-1 2,4-dibromoanisole 
• 100-66-3 methoxybenzene 
• 2737-22-6 2,4,6-tribromo-3-hydroxybenzaldehyde 
• 133871-69-9 2,4,6-tribromo-5-methoxybenzaldehyde 
• 4073-35-2 3,5-dibromo-4-methoxybenzoic acid 
• 7732-18-5 water 
• 7726-95-6 bromine 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 
• 118-79-6 2,4,6-tribromophenol 
• 634-89-9 1,2,3,5-tetrabromobenzene 
• 124-41-4 sodium methylate 
• 1189-09-9 methyl geranate 
• 186581-53-3 diazomethane 

Downstream Products

• 133932-61-3 5-bromo-2-methoxybenzene-1,3-diol 
• 99067-30-8 5-bromo-2-methoxyisophthalic acid 
• 79893-39-3 3,5-dibromo-2-methoxyphenol 
• 21702-84-1 2,4-dibromoanisole 
• 7463-93-6 2,4-dibromo-6-methyl-anisole 
• 76800-32-3 5,5'-dibromo-2,2'-dimethoxy-3,3'-dimethylbiphenyl 
• 76800-31-2 3,5,5'-tribromo-2,2'-dimethoxy-3'-methylbiphenyl 
• 151799-69-8 5-bromo-2-methoxy-1,3-phenylenebis(N-tert-butyl-N-hydroxyamine) 
• 201349-27-1 2,4,6-tribromo-3,5-dinitro-anisole 
• 873981-08-9 2,4,6-tribromo-3-nitro-anisole 
• 13130-23-9 3,5-dibromo-2-methoxybenzoic acid 
• 3140-01-0 2,4,6-triphenylphenol 
• 4647-83-0 2,4,6-triphenylphenoxyl 
• 10384-15-3 2,4,6-triphenyl-4-(2,4,6-triphenyl-phenoxy)-cyclohexa-2,5-dienone 

Relevant articles and documents

Zwitterionic-Salt-Catalyzed Site-Selective Monobromination of Arenes

A zwitterionic-salt-catalyzed electrophilic monobromination of arenes with high regioselectivity has been developed. Under mild reaction conditions, a wide range of monobrominated aromatic compounds can be obtained in excellent yields. The reaction can be operated using an extremely low catalyst loading (0.05 mol %) with the inexpensive brominating agent N-bromosuccinimide. The versatility of this catalytic protocol has been demonstrated by the scale-up reaction with a 0.01 mol % catalyst loading to provide the selectively halogenated compound in quantitative yield.

New synthesis of hydrangettn and collinin

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POLYBROMINATED AROMATIC COMPOUNDS. IV. METHOXYDEBROMINATION REACTIONS OF POLYBROMOBENZENES IN PYRIDINE

The rates were measured and the orientation was studied for the methoxydebromination of all polybromobenzenes C6HnBr6-n (n = 0-3) in pyridine at 115 deg C.From comparison of the partial rates of substitution of the bromine atom at various positions of the benzene ring it was found that the activating effect of the bromine atom in relation to the point of nucleophilic attack changes in the order o-Br > m-Br > p-Br, and the directing selectivity of the bromine is low (compared with fluorine in the methoxydefluorination of polyfluorobenzenes) and increases with decrease in the number of bromine atoms in the aromatic ring of the substrate.