74630-22-1Relevant academic research and scientific papers
β-Carbolines: synthesis of harmane, harmine alkaloids and their structural analogs by thermolysis of 4-aryl-3-azidopyridines and investigation of their optical properties
Shuvalov, Vladislav Yu.,Elisheva, Valeriya А.,Belousova, Anastasiya S.,Arshinov, Evgenii V.,Glyzdinskaya, Larisa V.,Vorontsova, Marina А.,Chernenko, Sergei А.,Fisyuk, Aleksander S.,Sagitullina, Galina P.
, p. 73 - 83 (2020/02/18)
[Figure not available: see fulltext.] Interest in β-carbolines is caused by the biological activity of these compounds and the use of their fluorescent properties in the study of their interaction with DNA and other biological targets, as well as with drug delivery vehicles. A new general method for the synthesis of harmane, harmine, and their structural analogs by thermolysis of substituted 4-aryl-3-azidopyridines was developed, and their optical properties were studied.
Recyclization of 1,4-dihydropyridine derivatives in acidic medium
Stupnikova,Petushkova,Muceniece,Lūsis
, p. 41 - 49 (2007/10/03)
The recyclization of 1,4-dihydropyridines in aqueous-alcoholic hydrochloric acid medium proceeds with cleavage of a C-N bond and pyridine ring opening. Cyclohexenone derivatives are formed as a result of the subsequent intramolecular crotonic condensation of the acyclic intermediate. The leaving carbonyl substituents depart simultaneously with recyclization, depending on the acidity of the reaction medium.
A Convenient Synthesis of 3-Cyano-2-methylpyridines under Ultrasonic Irradiation
Shibata, Katsuyoshi,Urano, Katsuyoshi,Matsui, Masaki
, p. 2199 - 2200 (2007/10/02)
Ultrasonic irradiation of α,β-unsaturated carbonyl compounds 1a-i with acetonitrile in the presence of pottasium t-butoxide gave 3-cyano-2-methylpyridines 2a-i in moderate to good yields.The pyridines are produced by a Michael reaction of 3-iminobutanonitrile, an acetonitrile dimer, to the substrates 1a-i.
