N-(2-chloroethyl)-1-methyl-4-nitro-1H-imidazole-5-carboxamide, also known as CCNU or lomustine, is a nitrosourea-based chemotherapeutic agent. It is a prodrug that is converted into its active form in the liver, where it undergoes metabolic activation to produce a reactive chloroethylating species. This active metabolite is capable of cross-linking DNA strands, which leads to the inhibition of DNA replication and transcription, ultimately resulting in cell death. CCNU is primarily used in the treatment of various types of cancer, including brain tumors, Hodgkin's disease, and non-Hodgkin's lymphoma. Due to its alkylating properties, it can cause significant side effects, such as myelosuppression, nausea, and vomiting. The drug is administered orally and is considered a first-line treatment option for certain types of cancer.
7464-69-9
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Basic information
- Product Name: N-(2-chloroethyl)-1-methyl-4-nitro-1H-imidazole-5-carboxamide
- Synonyms:
- CAS NO:7464-69-9
- Molecular Formula: C7H9ClN4O3
- Molecular Weight: 232.6244
- EINECS: N/A
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 520.7°C at 760 mmHg
- Flash Point: 268.7°C
- Appearance: N/A
- Density: 1.57g/cm3
- Vapor Pressure: 6.1E-11mmHg at 25°C
- Refractive Index: 1.638
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: N-(2-chloroethyl)-1-methyl-4-nitro-1H-imidazole-5-carboxamide(CAS DataBase Reference)
- NIST Chemistry Reference: N-(2-chloroethyl)-1-methyl-4-nitro-1H-imidazole-5-carboxamide(7464-69-9)
- EPA Substance Registry System: N-(2-chloroethyl)-1-methyl-4-nitro-1H-imidazole-5-carboxamide(7464-69-9)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 7464-69-9(Hazardous Substances Data)
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Check Digit Verification of cas no
The CAS Registry Mumber 7464-69-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,4,6 and 4 respectively; the second part has 2 digits, 6 and 9 respectively.Calculate Digit Verification of CAS Registry Number 7464-69:
(6*7)+(5*4)+(4*6)+(3*4)+(2*6)+(1*9)=119
119 % 10 = 9
So 7464-69-9 is a valid CAS Registry Number.
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N-(2-chloroethyl)-1-methyl-4-nitro-1H-imidazole-5-carboxamide
