74647-44-2

Basic information

• Product Name: ethyl 5'-acetyl-2'-amino-6'-methyl-1,3-dihydro-2-oxospiro[2H-indole-3,4'-(4'H)-pyran]-3'-carboxylate
• Synonyms: ethyl 5'-acetyl-2'-amino-6'-methyl-1,3-dihydro-2-oxospiro[2H-indole-3,4'-(4'H)-pyran]-3'-carboxylate
• CAS NO: 74647-44-2
• Molecular Formula: C18H18N2O5
• Molecular Weight: 342.34592
• Mol File: 74647-44-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 5'-acetyl-2'-amino-6'-methyl-1,3-dihydro-2-oxospiro[2H-indole-3,4'-(4'H)-pyran]-3'-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 5'-acetyl-2'-amino-6'-methyl-1,3-dihydro-2-oxospiro[2H-indole-3,4'-(4'H)-pyran]-3'-carboxylate(74647-44-2)
• EPA Substance Registry System: ethyl 5'-acetyl-2'-amino-6'-methyl-1,3-dihydro-2-oxospiro[2H-indole-3,4'-(4'H)-pyran]-3'-carboxylate(74647-44-2)

Safety Data

• Hazardous Substances Data: 74647-44-2(Hazardous Substances Data)

Upstream product

• 91-56-5 indole-2,3-dione 
• 504-02-9 1,3-cylohexanedione 
• 105-56-6 ethyl 2-cyanoacetate 
• 6532-16-7 1-(4-morpholinylmethyl)-1H-indole-2,3-dione 
• 123-54-6 acetylacetone 
• 14003-18-0 ethyl 2-(2-oxoindolin-3-ylidene)cyanoacetate 
• 14003-19-1 ethyl cyano-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)acetate 

Relevant articles and documents

Carbon-SO3H: A novel and recyclable solid acid catalyst for the synthesis of spiro[4H-pyran-3,3′-oxindoles]

A bioglycerol derived carbon-sulfonic acid is found to catalyze efficiently the three-component one-pot condensation of isatin, malononitrile, and 1,3-dicarbonyls to afford a wide range of spiro[4H-pyran-3,3′-oxindole] derivatives in good yields and selec

One-pot three-component synthesis of spirooxindoles catalyzed by hexamethylenetetramine in water

A simple, convenient, and multicomponent strategy for synthesis of spirooxindole derivatives has been developed. This strategy provides a rapid access to construct a diversity-oriented library of spirooxindoles by using three simple and readily available isatin, malononitrile or cyanoacetic ester, and 1,3-dicarbonyl compound catalyzed by hexamethylenetetramine in water.

Synthesis of fused 2′-amino-3′-R-spiro-[indole-3,4′- pyran]-2(1H)-ones

An efficient one-pot procedure has been proposed for the synthesis of fused 2′-amino-3′-R-spiro-[indole-3,4′-pyran]-2(1H)-ones via base-catalyzed three-component condensation of isatins with the corresponding nitriles and 1,3-diketones.