7465-58-9Relevant articles and documents
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Haddon,R.C. et al.
, p. 7629 - 7633 (1978)
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Exceptional oxygen sensing properties of new blue light-excitable highly luminescent europium(III) and gadolinium(III) complexes
Borisov, Sergey M.,Fischer, Roland,Saf, Robert,Klimant, Ingo
, p. 6548 - 6560 (2014)
New europium(III) and gadolinium(III) complexes bearing 8-hydroxyphenalenone antenna combine efficient absorption in the blue part of the spectrum and strong emission in polymers at room temperature. The Eu(III) complexes show characteristic red luminescence whereas the Gd(III) dyes are strongly phosphorescent. The luminescence quantum yields are about 20% for the Eu(III) complexes and 50% for the Gd(III) dyes. In contrast to most state-of-the-art Eu(III) complexes the new dyes are quenched very efficiently by molecular oxygen. The luminescence decay times of the Gd(III) complexes exceed 1 ms which ensures exceptional sensitivity even in polymers of moderate oxygen permeability. These sensors are particularly suitable for trace oxygen sensing and may be good substitutes for Pd(II) porphyrins. The photophysical and sensing properties can be tuned by varying the nature of the fourth ligand. The narrow-band emission of the Eu(III) allows efficient elimination of the background light and autofluorescence and is also very attractive for use e.g., in multi-analyte sensors. The highly photostable indicators incorporated in nanoparticles are promising for imaging applications. Due to the straightforward preparation and low cost of starting materials the new dyes represent a promising alternative to the state-of-the-art oxygen indicators particularly for such applications as, e.g., food packaging.
A safe and efficacious Pt(ii) anticancer prodrug: Design, synthesis,: In vitro efficacy, the role of carrier ligands and in vivo tumour growth inhibition
Dutta, Pradip Kumar,Sharma, Rupali,Kumari, Smita,Dubey, Ravindra Dhar,Sarkar, Sujit,Paulraj, Justin,Vijaykumar, Gonela,Pandey, Manoj,Sravanti,Samarla, Mallik,Das, Hari Sankar,Yashpal,Heeralal,Goyal, Ravinder,Gupta, Nimish,Mandal, Swadhin K.,Sengupta, Aniruddha,Sarkar, Arindam
supporting information, p. 1718 - 1721 (2019/02/12)
Diaminocyclohexane-Pt(ii)-phenalenyl complexes (1 and 2) showed an appropriate balance between efficacy and toxicity. Compound 2 showed nearly two-fold higher tumour growth inhibition than oxaliplatin in a murine NSCLC tumour model, when a combined drug development approach was used. The fluorescent properties of phenalenone were utilized to understand the mechanistic details of the drug.
FLUORESCENT ANTICANCER PLATINUM DRUGS
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Paragraph 0388, (2018/11/21)
The present disclosure is in relation to the field of nanotechnology and cancer therapeutics. In particular, the present disclosure relates to fluorescent platinum based compounds. The disclosure further relates to synthesis of said fluorescent platinum based compounds, nanoparticles and compositions comprising said fluorescent platinum based compounds/nanoparticles. The disclosure also relates to methods of managing cancer by the fluorescence changes between aforesaid platinum based compounds and corresponding free ligands, nanoparticles and compositions.
