74650-71-8

Basic information

• Product Name: 2-chloro-5-Methoxy-3-pyridinecarboxylic acid
• Synonyms: 2-chloro-5-Methoxy-3-pyridinecarboxylic acid;2-chloro-5-methoxypyridine-3-carboxylic acid
• CAS NO: 74650-71-8
• Molecular Formula: C₇H₆ClNO₃
• Molecular Weight: 187.58044
• Mol File: 74650-71-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 354.5±37.0 °C(Predicted)
• Appearance: /
• Density: 1.430±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 1.90±0.25(Predicted)
• CAS DataBase Reference: 2-chloro-5-Methoxy-3-pyridinecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-5-Methoxy-3-pyridinecarboxylic acid(74650-71-8)
• EPA Substance Registry System: 2-chloro-5-Methoxy-3-pyridinecarboxylic acid(74650-71-8)

Safety Data

• Hazardous Substances Data: 74650-71-8(Hazardous Substances Data)

Usage

General Description

2-chloro-5-methoxy-3-pyridinecarboxylic acid is a chemical compound with the molecular formula C7H6ClNO3. It is a chloro-substituted pyridine derivative with a methoxy group attached to the pyridine ring. 2-chloro-5-methoxy-3-pyridinecarboxylic acid is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It has been studied for its potential antifungal and anticancer properties, and it is also used as an intermediate in the production of various organic compounds. The presence of both a chloro and methoxy group makes this compound versatile for use in a wide range of chemical reactions and applications.

Upstream product

• 7732-18-5 water 
• 74650-70-7 2-chloro-5-methoxy-3-methylpyridine 
• 42959-40-0 2-Chlor-5-hydroxy-nicotinsaeure 
• 1256791-15-7 methyl 2-chloro-5-methoxynicotinate 
• 38186-82-2 6-chloro-5-methylpyridin-3-amine 
• 54232-03-0 2-chloro-5-hydroxy-3-methylpyridine 

Downstream Products

• 1256791-15-7 methyl 2-chloro-5-methoxynicotinate 
• 74650-77-4 (S)-5-benzyloxy-2-(3-t-butylamino-2-hydroxypropoxy)nicotinonitrile 
• 74650-76-3 5-benzyloxy-2-chloronicotinonitrile 
• 74650-73-0 2-chloro-3-cyano-5-methoxypyridine 

Relevant articles and documents

Pharmacological Evaluation of Novel Bioisosteres of an Adamantanyl Benzamide P2X7 Receptor Antagonist

Adamantanyl benzamide 1 was identified as a potent P2X7R antagonist but failed to progress further due to poor metabolic stability. We describe the synthesis and SAR of a series of bioisosteres of benzamide 1 to explore improvements in the pharmacological properties of this lead. Initial efforts investigated a series of heteroaromatic bioisosteres, which demonstrated improved physicochemical properties but reduced P2X7R antagonism. Installation of bioisosteric fluorine on the adamantane bridgeheads was well tolerated and led to a series of bioisosteres with improved physicochemical properties and metabolic stability. Trifluorinated benzamide 34 demonstrated optimal physicochemical parameters, superior metabolic stability (ten times longer than lead benzamide 1), and an improved physicokinetic profile and proved effective in the presence of several known P2X7R polymorphisms.

2-Substituted propoxy-3-cyano-5-RO-pyridines and intermediates

The present application discloses 2-substituted propoxy-3-cyano-5-RO-pyridines and intermediates therefor. The former compounds have pharmaceutical activity.