746596-00-9

Usage

Piperazine derivative

A chemical compound based on the piperazine structure This indicates that 2-(4-fluoro-2-methylphenyl)piperazine is derived from the basic structure of piperazine, which is a heterocyclic organic compound.

Fluorine atom

A halogen element attached to the phenyl ring The presence of a fluorine atom in the compound suggests that it is part of the phenyl ring, which is a ring of six carbon atoms connected by alternating single and double bonds.

Medicinal chemistry interest

Potential therapeutic applications due to interactions with the central nervous system This suggests that 2-(4-fluoro-2-methylphenyl)piperazine may have potential uses in the development of drugs or treatments for conditions related to the central nervous system.

Building block for synthesis

Used as a starting compound for the creation of various bioactive compounds This means that 2-(4-fluoro-2-methylphenyl)piperazine can be used as a base for the synthesis of other compounds that have biological activity, which could be used in the development of pharmaceuticals or other applications.

Hazards and proper handling

May pose hazards if not used properly This indicates that 2-(4-fluoro-2-methylphenyl)piperazine could be toxic or dangerous if not handled with care, and appropriate safety measures should be taken when working with this chemical.

Upstream product

• 107-15-3 ethylenediamine 
• 79784-33-1 4-fluoro-2-methylphenylglyoxal 
• 334477-08-6 3-(4-fluoro-2-methylphenyl)-5,6-dihydro-1H-pyrazin-2-one 
• 452-63-1 2-Bromo-5-fluorotoluene 

Downstream Products

• 1153574-55-0 (1R)-1-phenylethyl 3-(4-fluoro-2-methylphenyl)-1-piperazinecarboxylate 
• 334476-93-6 phenylmethyl 3-(4-fluoro-2-methylphenyl)-1-piperazinecarboxylate 

Relevant academic research and scientific papers

Biocatalytic Access to Piperazines from Diamines and Dicarbonyls

Given the widespread importance of piperazines as building blocks for the production of pharmaceuticals, an efficient and selective synthesis is highly desirable. Here we show the direct synthesis of piperazines from 1,2-dicarbonyl and 1,2-diamine substrates using the R-selective imine reductase from Myxococcus stipitatus as biocatalyst. Various N- and C-substituted piperazines with high activity and excellent enantioselectivity were obtained under mild reaction conditions reaching up to 8.1 g per liter.

Discovery of novel 2-(3-phenylpiperazin-1-yl)-pyrimidin-4-ones as glycogen synthase kinase-3β inhibitors

We herein describe the results of further evolution of glycogen synthase kinase (GSK)-3β inhibitors from our promising compounds containing a 2-phenylmorpholine moiety. Transformation of the morpholine moiety into a piperazine moiety resulted in potent GSK-3β inhibitors. SAR studies focused on the phenyl moiety revealed that a 4-fluoro-2-methoxy group afforded potent inhibitory activity toward GSK-3β. Based on docking studies, new hydrogen bonding between the nitrogen atom of the piperazine moiety and the oxygen atom of the main chain of Gln185 has been indicated, which may contribute to increased activity compared with that of the corresponding phenylmorpholine analogues. Effect of the stereochemistry of the phenylpiperazine moiety is also discussed.