7466-46-8

Usage

Uses

Used in Organic Synthesis:
2,3-Diphenyl-6-aminoquinoxaline is utilized as a building block in organic synthesis, contributing to the preparation of a diverse range of molecules and pharmaceuticals. Its structural features facilitate the creation of complex organic compounds, making it an essential component in the synthesis process.
Used in Research:
In the realm of scientific research, 2,3-Diphenyl-6-aminoquinoxaline serves as a fluorescent dye, allowing for the visualization and tracking of specific molecules or processes within a system. Its fluorescent properties are particularly useful in studies involving fluorescence microscopy or other imaging techniques.
Used in Photoreactive Compounds:
2,3-Diphenyl-6-aminoquinoxaline is also employed in the development of photoreactive compounds, which are sensitive to light and can undergo chemical reactions upon exposure. This property is valuable in various applications, such as photodynamic therapy or the synthesis of light-sensitive materials.
Used in Medicine:
Due to its potential applications in the medical field, 2,3-Diphenyl-6-aminoquinoxaline is being explored for its possible use in the development of new drugs and therapeutic agents. Its unique chemical structure may offer novel pathways for drug discovery and treatment of various diseases.
Used in Materials Science:
In the field of materials science, 2,3-Diphenyl-6-aminoquinoxaline is being investigated for its potential use in the creation of new materials with specific properties. Its chemical characteristics may contribute to the development of advanced materials with applications in electronics, photonics, or other high-tech industries.

InChI:InChI=1/C20H15N3/c21-16-11-12-17-18(13-16)23-20(15-9-5-2-6-10-15)19(22-17)14-7-3-1-4-8-14/h1-13H,21H2

Upstream product

• 7466-45-7 6-nitro-2,3-diphenylquinoxaline 
• 64-17-5 ethanol 
• 134-81-6 benzil 
• 615-71-4 benzene-1,2,4-triamine 
• 97-02-9 2,4-Dinitroanilin 
• 99-56-9 4-Nitrophenylene-1,2-diamine 
• 7647-01-0 hydrogenchloride 

Downstream Products

• 159803-05-1 diethyl 2-(2,3-diphenylquinoxalin-6-ylaminomethylene)malonate 

Relevant academic research and scientific papers

Structure activity relationship (SAR) study identifies a quinoxaline urea analog that modulates IKKβ phosphorylation for pancreatic cancer therapy

Genetic models validated Inhibitor of nuclear factor (NF) kappa B kinase beta (IKKβ) as a therapeutic target for KRAS mutation associated pancreatic cancer. Phosphorylation of the activation loop serine residues (S177, S181) in IKKβ

Thiazolo[5,4-f]quinoxalines, Oxazolo[5,4-f]quinoxalines and Pyrazino[b,e]isatins: Synthesis from 6-Aminoquinoxalines and Properties

The regioselective iodination of different 2-mono-, 3-mono- and 2,3-disubstituted 6-aminoquinoxalines, which takes place at their 5-position, was rationalized on the basis of Hückel theory calculations. Oxazolo- and thiazolo[5,4-f]quinoxaline analogues of

Design, synthesis and biological evaluation of novel fluorinated heterocyclic hybrid molecules based on triazole & quinoxaline scaffolds lead to highly potent antimalarials and antibacterials

A series of novel fluorinated heterocyclic hybrid molecules based on triazole & quinoxaline scaffold were designed, synthesized and evaluated for inhibition of Plasmodium falciparum, a virulent human malaria parasite. Mono and bis triazole tagged quinoxal

Emergence of pyrido quinoxalines as new family of antimalarial agents

A series of novel N-alkyl dihydro pyrido quinoxaline derivatives were synthesized using Gould-Jacobs reaction and evaluated their antimalarial activity in vitro against chloroquine sensitive (3D7) and drug resistant (Dd2) strains of Plasmodium falciparum.

A new facile, efficient synthesis and structure peculiarity of quinoxaline derivatives with two benzimidazole fragments

A highly efficient and versatile method for the synthesis of quinoxaline derivatives with two benzimidazole fragments have been developed on the basis of the ring contraction of 3-(benzimidazo-2-yl)quinoxalin-2(1H)-one with 1,2-diaminobenzene and its various types of substituted and condensed derivatives. Owing to the inter- and intramolecular processes, involving self association, proton exchange, conformational, and/or tautomeric exchanges between several forms for most of the bis-benzimidazolylquinoxalines signals of bridged and neighboring carbon atoms and the hydrogen atoms of the neighboring carbon atoms of benzimidazole fragments in the NMR spectra are broadened. The conjugation between the benzimidazole fragments and the quinoxaline core of the molecules is increased from the quinoxaline derivative (10c) to its thiadiazol[f]- (17) and pyrrolo[a]-(19) annulated derivatives, resulting in a greater planarity of the molecule as a whole.

Perturbing pro-survival proteins using quinoxaline derivatives: A structure-activity relationship study

In HeLa cells the combinatorial knockdown of Bcl-xL and Mcl-1 is sufficient to induce spontaneous apoptosis. Quinoxaline derivatives were screened for the induction of Mcl-1 dependent apoptosis using a cell line without functional Bcl-xL. Quinoxaline urea

2,3-Substituted quinoxalin-6-amine analogs as antiproliferatives: A structure-activity relationship study

The quinoxaline core is considered a privileged scaffold as it is found in a variety of biologically relevant molecules. Here we report the synthesis of a quinoxalin-6-amine library, screening against a panel of cancer cell lines and a structure-activity

Quinoxalinylurea derivatives as a novel class of JSP-1 inhibitors

A series of quinoxalinylurea-based inhibitors are synthesized and shown to be the novel and potent inhibitors against Jnk Stimulatory Phosphatase-1 (JSP-1), which is a special member of dual-specificity protein phosphatase (DSP) family. Biological assay a

Synthesis and antiprotozoal activity of some new synthetic substituted quinoxalines

A series of 29 new quinoxalines was synthesized and evaluated in vitro against several parasites (Leishmania donovani, Trypanosoma brucei brucei, and Trichomonas vaginalis). Several of them displayed interesting activities, and particularly four quinoxaline amides showed in vitro antileishmanial properties (IC50 less than 20 μM).

General microwave-assisted protocols for the expedient synthesis of quinoxalines and heterocyclic pyrazines

Functionalized quinoxalines and heterocyclic pyrazines are expediently prepared in excellent yields (69-99%) from common 1,2-diketone intermediates under microwave irradiation. In addition to being general for a variety of aryl/heteroaryl 1,2-diamines and