7466-73-1

Usage

Uses

Used in Fluorescent Dyes:
2-HYDROXY-10H-ACRIDIN-9-ONE is used as a fluorescent dye for its bright yellow-green fluorescence, making it suitable for applications in fluorescence microscopy and other imaging techniques.
Used in Synthesis of Pharmaceuticals:
In the pharmaceutical industry, 2-HYDROXY-10H-ACRIDIN-9-ONE is used as a key intermediate in the synthesis of various drugs, contributing to the development of new therapeutic agents.
Used in Synthesis of Agrochemicals:
Similarly, in the agrochemical sector, 2-HYDROXY-10H-ACRIDIN-9-ONE serves as a crucial component in the synthesis of pesticides and other crop protection products, enhancing agricultural productivity.
Used in Antimicrobial Applications:
2-HYDROXY-10H-ACRIDIN-9-ONE is studied for its potential antimicrobial properties, which could be utilized in the development of new antimicrobial agents to combat resistant bacteria and other pathogens.
Used in Antitumor Applications:
2-HYDROXY-10H-ACRIDIN-9-ONE has been investigated for its antitumor properties, indicating its potential use in cancer research and the development of novel anticancer drugs.
Used as a pH Indicator:
2-HYDROXY-10H-ACRIDIN-9-ONE is also used as a pH indicator in acidic solutions, where its fluorescence properties can be leveraged to measure pH changes.
It is important to handle 2-HYDROXY-10H-ACRIDIN-9-ONE with care, as it may pose toxicity and health risks if ingested or inhaled.

InChI:InChI=1/C13H9NO2/c15-8-5-6-12-10(7-8)13(16)9-3-1-2-4-11(9)14-12/h1-7,15H,(H,14,16)

Upstream product

• 75843-49-1 2-ethoxy-9-chloro-acridine 
• 61556-11-4 9-acridone-2-sulfonic acid 
• 13278-33-6 N-p-ethoxyphenylanthranilic acid 
• 13501-67-2 N-(p-methoxyphenyl)anthranilic acid 
• 578-95-0 10H-acridin-9-one 
• 91-40-7 2-(phenylamino)benzoic acid 
• 104-94-9 4-methoxy-aniline 
• 49742-72-5 2-methoxy-9(10H)-acridinone 
• 118-91-2 ortho-chlorobenzoic acid 

Downstream Products

• 49742-72-5 2-methoxy-9(10H)-acridinone 
• 1370524-12-1 10-benzyloxycarbonyl-2-(benzyloxycarbonyl)oxy-9,10-dihydroacridine 
• 22817-17-0 acridin-2-ol 

Relevant academic research and scientific papers

Sulfonic acid-catalyzed autoxidative carbon-carbon coupling reaction under elevated partial pressure of oxygen

An aerobic organocatalytic oxidative C-C bond formation reaction of benzylic C-H bonds with various C-nucleophiles is described. The coupling reaction proceeds by simply stirring the substrates under elevated partial pressure of oxygen in the presence of a sulfonic acid catalyst at room temperature. Elevation of the pressure enables the reaction of a broad scope of nucleophile substrates otherwise showing poor reactivity at ambient pressure. The benzylic C-H bonds of xanthene, acridanes, isochromane and related heterocycles could be functionalized with nucleophiles including ketones, 1,3-dicarbonyl compounds and aldehydes. Electron-rich arenes could be utilized as nucleophiles at elevated temperatures. The reactions are believed to proceed via autoxidation of the benzylic C-H bonds to the hydroperoxides and subsequent nucleophilic substitution catalyzed by sulfonic acids. Copyright

Structure-activity relationship studies of acridones as potentialantipsoriatic agents.1.Synthesis and antiproliferative activity of simple N-unsubstituted 10H-acridin-9-ones against human keratinocyte growth

A series of N-unsubstituted hydroxy-10H-acridin-9-ones were synthesized and evaluated for inhibitory action against HaCaT keratinocyte growth,in order to explore their potential as antipsoriatic agents. For structureeactivity relationship studies,the numb

Acridone derivatives: Design, synthesis, and inhibition of breast cancer resistance protein ABCG2

The breast cancer resistance protein (BCRP, ABCG2) is among the latest discovered ABC proteins to be involved in MDR phenotype and for which only few inhibitors are known. In continuing our program aimed at discovering efficient multidrug resistance modul

Synthesis and structure-activity relationships of anti-inflammatory 9,10-dihydro-9-oxo-2-acridine-alkanoic acids and 4-(2-carboxyphenyl)aminobenzenealkanoic acids

Eighteen test compounds, in three chemical series, were prepared as potential anti-inflammatory agents and evaluated by the rat hindpaw carrageenan-induced edema assay. The compounds, isosteric with known anti-inflammatory and antiallergic cyclo-oxygenase