Welcome to LookChem.com Sign In|Join Free

CAS

  • or

49742-72-5

Post Buying Request

49742-72-5 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

49742-72-5 Usage

Description

2-Methoxy-10H-acridin-9-one, also known as acridine yellow, is a chemical compound with the molecular formula C14H11NO2. It is a yellow to orange crystalline powder that is insoluble in water and soluble in organic solvents. 2-methoxy-10H-acridin-9-one has been utilized in various scientific and industrial applications due to its unique properties.

Uses

Used in Laboratory Applications:
2-Methoxy-10H-acridin-9-one is used as a fluorescent dye for staining DNA and RNA in cells and tissues, which aids in the visualization and analysis of these biomolecules in biological and medical research.
Used as a Histological Stain:
In histology, 2-Methoxy-10H-acridin-9-one serves as a stain to color and differentiate cellular structures, facilitating the study of tissue morphology and the diagnosis of diseases.
Used as a pH Indicator:
2-Methoxy-10H-acridin-9-one functions as a pH indicator, changing color from red to yellow within the pH range of 4.4 to 6.0, which is useful for monitoring acid-base conditions in various laboratory settings.
Used in Pharmaceutical Research:
2-methoxy-10H-acridin-9-one has been studied for its potential anti-cancer properties, making it a candidate for the development of new therapeutic agents against cancer.
Used in Microbiological Research:
2-Methoxy-10H-acridin-9-one has also been investigated for its anti-microbial properties, which could lead to its use in the development of new antimicrobial agents.
Used in Material Science:
Furthermore, 2-Methoxy-10H-acridin-9-one has been explored for its potential use in the development of new materials and technologies, indicating its versatility in scientific research and innovation.

Check Digit Verification of cas no

The CAS Registry Mumber 49742-72-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,9,7,4 and 2 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 49742-72:
(7*4)+(6*9)+(5*7)+(4*4)+(3*2)+(2*7)+(1*2)=155
155 % 10 = 5
So 49742-72-5 is a valid CAS Registry Number.
InChI:InChI=1/C14H11NO2/c1-17-9-6-7-13-11(8-9)14(16)10-4-2-3-5-12(10)15-13/h2-8H,1H3,(H,15,16)

49742-72-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-methoxy-10H-acridin-9-one

1.2 Other means of identification

Product number -
Other names 2-methoxy-9-acridanone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:49742-72-5 SDS

49742-72-5Relevant articles and documents

Access to acridones by tandem copper(i)-catalyzed electrophilic amination/Ag(i)-mediated oxidative annulation of anthranils with arylboronic acids

Huang, Yan-Xia,Huang, Zhuo-Jun,Jiang, Chun-Yong,Liang, Jing-Yi,Liang, Qiu-Ping,Shu, Bing,Xie, Hui,Zeng, Jun-Yi,Zhang, Shang-Shi,Zhou, Binhua

supporting information, p. 8487 - 8491 (2021/10/20)

An efficient and practical approach for the synthesis of medicinally important acridones was developed from anthranils and commercially available arylboronic acids by a tandem copper(i)-catalyzed electrophilic amination/Ag(i)-mediated oxidative annulation strategy. This new and straightforward protocol displayed a broad substrate scope (25 examples) and high functional group tolerance. What's more, a possible mechanistic proposal was also presented.

Design, synthesis and biological evaluation of acridone analogues as novel STING receptor agonists

Chang, Jia-jia,Hou, Shi,Lan, Xiu-juan,Li, Song,Li, Wei,Sun, Wei,Xiao, Jun-hai,Yan, Xin-lin,Yang, Xiao-hong

, (2020/01/09)

STING (Stimulator of Interferon Genes) has become a focal point in immunology research and a target in drug discovery. The discovery of a potent human-STING agonist is expected to revolutionize current anti-virus or cancer immunotherapy. Inspired by the structure and function of murine STING-specific agonists (DMXAA and CMA), we rationally designed and synthesized four series of novel compounds for the enhancement of human sensitivity. In the cell-based assay, we identified six compounds from all the synthetic small molecules: 2g, 9g, and 12b are STING agonists that are efficacious across species, and all have the skeleton of acridone; 1b, 1c, and 12c just function in the murine STING pathway. Notably, 12b exhibits the best activity among the six agonists, and its inductions of both human and murine STING-dependent signalling are similar to that of 2′3′-cGAMP, which is a well-known STING inducer. While a protein assay indicated that 2 g, 9 g, and 12b could activate the pathway by directly binding human STING, 12b also displayed the strongest binding affinity. Additionally, our studies show that 12b can induce faster, more powerful, and more durable responses of assorted cytokines in a native system than 2′3′-cGAMP. Consequently, our team is the first to successfully modify murine STING agonists to obtain human sensitivity, and these results suggest that 12b is a potent direct-human-STING agonist. Additionally, the acridone analogues demonstrate tremendous potential in the treatment of tumours or viral infections.

Acridone derivative containing amino sugar structure, and preparation method and application thereof (by machine translation)

-

, (2020/01/12)

The invention belongs to, the technical field of pharmaceutical chemistry, and particularly relates, to a preparation method of an acridone derivative containing an. amino sugar structure and a preparation method of the acridone derivative containing an a

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 49742-72-5