746607-87-4

Upstream product

• 2375-76-0 1-chloro-1,1-difluoropentane-2,4-dione 
• 832746-57-3 4-(chlorodifluoromethyl)-3,6-dimethyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine 

Relevant academic research and scientific papers

A general strategy for the synthesis of difluoromethyl-containing pyrazoles, pyridines and pyrimidines

Difluoromethyl-containing heteroannulated pyridines, pyrimidines and pyrazoles are prepared by a two step method. The regioselective cyclizations of electron-excessive aminoheterocycles, hydrazines and amidines with CF 2Cl-substituted 1,3-dicarbonyl compounds provide the corresponding CF2Cl-substituted heterocycles. Subsequent radical reactions with trimethylstannane or allyltrimethylstannane gave difluoromethyl-containing heteroannulated pyridines, pyrimidines and pyrazoles, respectively.