746640-19-7

Basic information

• Product Name: 4H-1-Benzopyran-4-one, 7-hydroxy-3-phenyl-2-[(4-pyridinylmethyl)thio]-
• CAS NO: 746640-19-7
• Molecular Formula: C21H15NO3S
• Molecular Weight: 361.421
• Mol File: 746640-19-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4H-1-Benzopyran-4-one, 7-hydroxy-3-phenyl-2-[(4-pyridinylmethyl)thio]-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-1-Benzopyran-4-one, 7-hydroxy-3-phenyl-2-[(4-pyridinylmethyl)thio]-(746640-19-7)
• EPA Substance Registry System: 4H-1-Benzopyran-4-one, 7-hydroxy-3-phenyl-2-[(4-pyridinylmethyl)thio]-(746640-19-7)

Safety Data

• Hazardous Substances Data: 746640-19-7(Hazardous Substances Data)

Upstream product

• 18439-96-8 1-(2-hydroxy-4-methoxyphenyl)-2-phenylethanone 
• 73870-24-3 4-bromomethyl pyridine hydrobromide 
• 39604-80-3 1-[2-hydroxy-4-(phenylmethoxy)phenyl]-2-phenylethanone 
• 3669-41-8 1-(2,4-dihydroxyphenyl)-2-phenylethanone 
• 746640-15-3 3-phenyl-7-(phenylmethoxy)-2-[(pyridin-4-ylmethyl)thio]-4H-1-benzopyran-4-one 
• 746640-10-8 7-methoxy-3-phenyl-2-[(pyridin-4-ylmethyl)thio]-4H-1-benzopyran-4-one 

Downstream Products

• 869801-08-1 7-(biphenyl-4-ylmethoxy)-3-phenyl-2-(pyridin-4-ylmethylsulfanyl)-chromen-4-one 
• 869800-99-7 7-(naphthalen-1-ylmethoxy)-3-phenyl-2-(pyridin-4-ylmethylsulfanyl)-chromen-4-one 

Relevant articles and documents

Heteroaryl-containing isoflavones as aromatase inhibitors

Compounds and methods useful for treating and prevention of cancer, particularly hormone-dependent breast cancer. Provided are compounds of formula I: wherein X is selected from O, N, S, SO, SO2, and S(CH2)n, wherein n=1-1

Synthesis and aromatase inhibitory activity of novel pyridine-containing isoflavones

Aromatase, a cytochrome P450 hemoprotein that is responsible for estrogen biosynthesis by conversion of androgens into estrogens, has been an attractive target in the treatment of hormone-dependent breast cancer. As a result, a number of synthetic steroidal or nonsteroidal aromatase inhibitors have been successfully developed. In addition, there are several classes of natural products that exert potent activities in aromatase inhibition, with the flavonoids being most prominent. Previous studies have exploited flavone and flavanone scaffolds for the development of new aromatase inhibitors. In this paper, we describe the design, synthesis, and biological evaluation of a novel series of 2-(4′-pyridylmethyl)thioisoflavones as the first example of synthetic isoflavone-based aromatase inhibitors.