869801-08-1Relevant articles and documents
Lead optimization of 7-benzyloxy 2-(4′-pyridylmethyl)thio isoflavone aromatase inhibitors
Su, Bin,Hackett, John C.,Diaz-Cruz, Edgar S.,Kim, Young-Woo,Brueggemeier, Robert W.
, p. 6571 - 6577 (2007/10/03)
Aromatase, the enzyme responsible for estrogen biosynthesis, is a particularly attractive target in the treatment of hormone-dependent breast cancer. The synthesis and biological evaluation of a series of 2-(4′-pyridylmethyl)thio, 7-alkyl- or aryl-substit