746657-36-3Relevant articles and documents
CALPAIN MODULATORS AND METHODS OF PRODUCTION AND USE THEREOF
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, (2017/09/27)
The present technology relates to compounds, kits, compositions, and methods useful for the treatment of fibrotic disease. In some aspects, the present technology provides for treatment of various diseases or disorders associated or mediated, at least in part, by calpains, such as CAPN1, CAPN2, and/or CAPN9. The present technology is generally applicable to compounds which inhibit myofibroblast differentiation.
Synthesis of bis-macrocyclic HCV protease inhibitor mk-6325 via intramolecular sp 2- sp 3 Suzuki-Miyaura coupling and ring closing metathesis
Li, Hongmei,Scott, Jeremy P.,Chen, Cheng-Yi,Journet, Michel,Belyk, Kevin,Balsells, Jaume,Kosjek, Birgit,Baxter, Carl A.,Stewart, Gavin W.,Wise, Christopher,Alam, Mahbub,Song, Zhiguo Jake,Tan, Lushi
supporting information, p. 1533 - 1536 (2015/03/30)
A practical asymmetric synthesis of the complex fused bis-macrocyclic HCV protease inhibitor MK-6325 (1) is described. Through the combination of a high yielding and low catalyst loading ring-closing metathesis (RCM) to forge the 15-membered macrocycle with an intramolecular sp2-sp3 Suzuki-Miyaura cross-coupling to append the 18-membered macrocycle, multikilogram access to the unique and challenging architecture of MK-6325 (1) has been achieved.
ENZYMES AND METHODS FOR RESOLVING AMINO VINYL CYCLOPROPANE CARBOXYLIC ACID DERIVATIVES
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Page/Page column 14-15, (2011/02/24)
Preparation and isolation of amino vinyl cyclopropane carboxylic acid derivatives and salts thereof, methods of resolving enantiomers, and methods of identifying compositions and/or enzymes that are capable of resolving racemic or partially enantiomerically enriched mixtures.