74667-98-4

Basic information

• Product Name: (E)-1-(dimethylamino)-4,4-dimethylpent-1-en-3-one
• CAS NO: 74667-98-4
• Molecular Weight: 155.24
• Mol File: 74667-98-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (E)-1-(dimethylamino)-4,4-dimethylpent-1-en-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-(dimethylamino)-4,4-dimethylpent-1-en-3-one(74667-98-4)
• EPA Substance Registry System: (E)-1-(dimethylamino)-4,4-dimethylpent-1-en-3-one(74667-98-4)

Safety Data

• Hazardous Substances Data: 74667-98-4(Hazardous Substances Data)

Upstream product

• 53400-42-3 N,N-dimethyl-N-(4,4-dimethyl-3-oxopentyl)ammonium chloride 
• 68-12-2 N,N-dimethyl-formamide 
• 75-97-8 3,3-dimethyl-butan-2-one 
• 1186-70-5 bis(dimethylamino)methoxymethane 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 52421-65-5 N,N-dimethyl-N'-thiobenzoylformamidine 
• 22700-73-8 1-(dimethylamino)-4,4-dimethylpentan-3-one 
• 5469-26-1 1-Bromopinacolon 
• 124-40-3 dimethyl amine 
• 145930-89-8 (3,3-Dimethyl-2-oxo-butylsulfanylmethylene)-dimethyl-ammonium; bromide 

Relevant articles and documents

Selective α-Methylation of Ketones

The convenient and scalable preparative approach for the two-step α-methylation of ketones is described. The optimized protocols for regioselective preparation of enaminones with further diastereoselective and functional groups tolerant hydrogenation to α-methylketones are developed. The scope and limitations of the proposed methodology are discussed. The advantages compared to known procedures are demonstrated. The unexpected role of acetone in the hydrogenation is suggested. The evaluation of the method for both early building block synthesis and late-stage CH-functionalization is shown. The elaborate procedures' preparability and scalability are demonstrated by the synthesis of several α-methyl ketones up to 100 g amount.

PYRIDO PYRIMIDINONES, DIHYDRO PYRIMIDO PYRIMIDINONES AND PTERIDINONES USEFUL AS RAF KINASE INHIBITORS

The present invention provides compounds having the formula: (I) wherein A-B together represents one of the following structures; (II), (III), (IV) and n, R1, R2, R3, R4, L1, L2, Y and Z are as defined in classes and subclasses herein, and pharmaceutical compositions thereof, as described generally and in subclasses herein, which compounds are useful as inhibitors of protein kinase (e.g., RAF), and thus are useful, for example, for the treatment of RAF mediated diseases.

Palladium-Promoted Transformation of β-Amino Ketones to Enaminones

The reaction of β-amino ketones with bis(acetonitrile)dichloropalladium(II) in the presence of triethylamine gives the corresponding enaminones regioselectively.The cyclic β-amino ketones can be converted into the corresponding exocyclic enaminones.The enaminones thus obtained are versatile synthetic intermediates.The reaction of (E)-enaminones with organocuprates gave the corresponding (E)-α,β-unsaturated ketones.