74670-12-5

Upstream product

• 3739-97-7 (trimethylsilyl)methylenetriphenylphosphorane 
• 315241-32-8 C₁₆H₁₄O₆C₆H₁₄Si 
• 201230-82-2 carbon monoxide 
• 20469-65-2 1-bromo-3,5-dimethoxybenzene 
• 118-93-4 o-hydroxyacetophenone 
• 7311-34-4 3,5-dimethoxybenzaldehdye 
• 582-24-1 1-phenyl-2-hydroxyethanone 
• 1132-21-4 3,5-dimethoxybenzoic acid 
• 315241-08-8 3,5-Dimethoxy-benzoic acid 2-carboxy-phenyl ester 
• 17213-57-9 3,5-dimethoxybenzoyl chloride 
• 2150-37-0 methyl 3,5-dimethoxybenzoate 
• 579-74-8 2-Methoxyacetophenone 
• 1403475-64-8 2-[3-(3,5-dimethoxyphenyl)propioloyl]phenyl acetate 

Downstream Products

• 1370734-40-9 ethyl 2?(2?(3,5?dimethoxyphenyl)?4?oxo?4H?chromen?3?yl)acetate 
• 1370734-46-5 3-(2-(4-chlorophenyl)-2-oxoethyl)-2-(3,5-dimethoxyphenyl)-4H-chromen-4-one 
• 1370734-51-2 3-(2-(biphenyl-4-yl)-2-oxoethyl)-2-(3,5-dimethoxyphenyl)-4H-chromen-4-one 

Relevant academic research and scientific papers

Divergent synthesis of flavones and flavanones from 2′-hydroxydihydrochalconesviapalladium(ii)-catalyzed oxidative cyclization

Divergent and versatile synthetic routes to flavones and flavanonesviaefficient Pd(ii) catalysis are disclosed. These Pd(ii) catalyses expediently provide a variety of flavones and flavanones from 2′-hydroxydihydrochalcones as common intermediates, depending on oxidants and additives,viadiscriminate oxidative cyclization sequences involving dehydrogenation, respectively, in a highly atom-economic manner.

Metal-Free, DBU-Mediated, Microwave-Assisted Synthesis of Benzo[c]xanthones by Tandem Reactions of Alkynyl-1,3-diketones

A base-mediated, green, microwave-assisted efficient preparation of a diverse benzoxanthone library from variety of readily accessible γ-alkynyl 1,3-diketones is reported. The synthesis is based on tandem reactions involving intramolecular cyclization, propargyl-allenyl isomerization, and electrocyclization in one pot. Some of the benzoxanthones are also synthesized by the one-pot reaction of 1,3-diketone and alkynyl bromide under basic heating conditions. This transformation also results in the construction of one new C?C bond and one new C?O bond. (Figure presented.).

Guanidino-graphene catalysed synthesis of flavones via Aldol-Michael-oxidation

Guanidino-graphene has been synthesized by the reaction of bromoamine with reduced graphene oxide and characterized by FT-IR, Raman, TGA, powder XRD, TEM, SEM, and zeta potential. It is a cheap, heterogeneous and environmentally benign solid base catalyst used for cascade Aldol-Michael-oxidation in the synthesis of chalcone, flavonoids.

Synthesis of B-ring substituted flavones and evaluation of their antitumor and antioxidant activities

A series of flavones, substituted at the ring B, were synthesized using either Claisen-Schimdt Condensation or Baker-Venkataraman rearrangement. The synthesized compounds were tested for in vitro cytotoxic activity by sulforhodamine B assay against three cell lines of different origin, viz. HepG2, MCF-7, and MOLT-4. The compounds were also tested for a possible antioxidant activity by determination of inhibition of lipid peroxidation. Quercetin was taken as a standard for antioxidant activity. Compound 1c showed the highest cytotoxic activity against MCF-7 (GI50 0.1 μM) and MOLT-4 (GI50 0.1 μM) cell lines and was comparable to adriamycin, the standard used. Compounds 1b, 1g, and 1h also showed promising activity against MCF-7 and MOLT-4 cell lines. In the absence of a hydroxyl group, one or more methoxy groups present on the B-ring (compounds 1c-1e) were major determinants of inhibition of lipid peroxidation.

Synthesis of flavones and γ-benzopyranones using mild sonogashira coupling and 18-crown-6 ether mediated 6-endo cyclization

An efficient method for the synthesis of flavones and γ- benzopyranones has been developed utilizing a mild Sonogashira coupling and 18-crown-6 ether mediated 6-endo cyclization of o-alkynoylphenyl acetates. By using this strategy, flavones and γ-benzopyranones bearing electron-donating groups, halogens, and simple alkyl substituents were synthesized in satisfactory yields. A facile, mild, and selective method for the synthesis of flavones and γ-benzopyranones is reported. o-Alkynoylphenyl acetates were obtained from either acyl chloride derivatives or substituted salicylates. Upon removing the acetate group, flavones and γ- benzopyranones were synthesized within 15 min with the aid of 18-crown-6 ether. A library of flavones and γ-benzopyranones was established. Copyright

Palladium-catalyzed carbonylation reaction of aryl bromides with 2-hydroxyacetophenones to form flavones

Flavone of the month: A general and efficient method for the palladium-catalyzed carbonylative synthesis of flavones has been developed (see scheme). Starting from aryl bromides and 2-hydroxyacetophenones, the corresponding flavones have been isolated in good yields. Copyright

A Novel Synthesis of 4H-Chromen-4-ones via Intramolecular Wittig Reaction

formula presented The acylphosphoranes formed in a sequential manner from the reaction of the silyl ester of O-acyl(aroyl)salicylic acids and (trimethylsilyl)-methylenetriphenylphosphorane undergo intramolecular Wittig cyclization on the ester carbonyl to afford the 4H-chromen-4-ones in good to excellent yields.