7469-49-0

Basic information

• Product Name: dibutyl (4-methylbenzene-1,3-diyl)biscarbamate
• CAS NO: 7469-49-0
• Molecular Formula: C₁₇H₂₆N₂O₄
• Molecular Weight: 322.3993
• Mol File: 7469-49-0.mol

Chemical Properties

• Boiling Point: 370.4°C at 760 mmHg
• Flash Point: 177.8°C
• Density: 1.136g/cm³
• Vapor Pressure: 1.11E-05mmHg at 25°C
• Refractive Index: 1.554
• CAS DataBase Reference: dibutyl (4-methylbenzene-1,3-diyl)biscarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: dibutyl (4-methylbenzene-1,3-diyl)biscarbamate(7469-49-0)
• EPA Substance Registry System: dibutyl (4-methylbenzene-1,3-diyl)biscarbamate(7469-49-0)

Safety Data

• Hazardous Substances Data: 7469-49-0(Hazardous Substances Data)

Upstream product

• 6935-99-5 2,4-bis(methoxycarbonylamino)toluene 
• 124-38-9 carbon dioxide 
• 95-80-7 4-methylbenzene-1,3-diamine 
• 592-35-8 butyl carbamate 
• 584-84-9 2,4-Toluene diisocyanate 
• 71-36-3 butan-1-ol 
• 57-13-6 urea 
• 100616-00-0 (3-isocyanato-4-methyl-phenyl)-carbamic acid butyl ester 

Downstream Products

• 584-84-9 2,4-Toluene diisocyanate 

Relevant articles and documents

Synthesis and antitussive activity of obtucarbamate A derivatives

Obtucarbamate A was purified from Disporum cantoniense with good antitussive property. In present work, a series of obtucarbamate A derivatives were designed and synthesized from obtucarbamate A by microwave method, and their antitussive activity were evaluated. The results showed that the toluene diisocyanate was obtained with a yield of 95.1percent using a simple method, 1-methyl-2-pyrrolidinone as solvent, temperature of 190 °C, microwave irradiation at 60 W power for 30 min. All compounds have good antitussive activity, and small steric hindrance unsaturated groups of ester chains and amino groups favor activity. It is the first reported of obtucarbamate A derivatives used as antitussive, and the results provide a basis for the application of obtucarbamate derivatives as new antitussive.

MULTISTEP PROCESS FOR THE PREPARATION OF HEXAMETHYLENE DIISOCYANATE, PENTAMETHYLENE DIISOCYANATE OR TOLUENE DIISOCYANATE

The present invention relates to a multistep process for the preparation of organic diisocyanates by converting the corresponding diamine precursors, urea and hydroxy compounds into monomeric diurethanes, converting these diurethanes into diurethanes of high boiling hydroxy compounds, and finally cleavage of the latter diurethanes to form the diisocyanates and recover the high boiling hydroxy compounds.

Halogen-Free Synthesis of Carbamates from CO2 and Amines Using Titanium Alkoxides

A direct synthesis of carbamates from amines and carbon dioxide in the presence of Ti(OR)4 (R=nBu (1), Me (2), Et (3), nPr (4)) was investigated. Aniline was reacted with titanium n-butoxide (1) in the presence of carbon dioxide (5 MPa) to give the corresponding n-butyl N-phenylcarbamate (BPC) in nearly quantitative yield (99 %) within 20 min. Furthermore, 1 could be regenerated upon reaction with n-butanol during water removal. The recovered 1 could then be reused in a subsequent reaction.

Method of manufacturing dicarbamate compsn. toluene, and, toluene diisocyanate

PROBLEM TO BE SOLVED: To provide a method for producing a toluene dicarbamate, by which the production of by-products can be reduced, to provide the toluene dicarbamate obtained by the production method, and to provide a method for producing toluene diisocyanate, for the production of the toluene diisocyanate from the toluene dicarbamate. SOLUTION: The method for producing the toluene dicarbamate is characterized by reacting toluene diamine with an N-nonsubstituted carbamate in the presence of an alcohol in the absence of urea. COPYRIGHT: (C)2012,JPOandINPIT

Insights into the organocatalyzed synthesis of urethanes in supercritical carbon dioxide: An in Situ FTIR spectroscopic kinetic study

The kinetics of urethane (carbamate) formation in supercritical CO 2 (scCO2) has been studied by in situ FTIR spectroscopy by using the reaction between n-butanol and toluene-2,4-diisocyanate as a model for the synthesis of polyureth

Selective derivatization of oxime-blocked tolylene-2,4-diisocyanate

A selective reaction of cyclohexanone oxime-blocked tolylene-2,4- diisocyanate (2,4-TDI) with amino siloxane was observed, in which amines were capable of discriminating two reactive groups in the 2,4-TDI molecule. Thus, tolylene-2-tert-butyldimethylsilyloxyethyl carbamide-4-cyclohexanone oxime carbamate was synthesized and its precise structure was determined by single-crystal X-ray diffraction. Moreover, it was found that oxime-blocked isocyanate could react selectively with the NH2 group with the OH group unprotected in ethanolamine.

METHOD FOR PRODUCING TOLUENEDICARBAMATE, METHOD FOR PRODUCING TOLUENEDIISOCYANATE, AND TOLUENEDICARBAMATE

A method for producing toluenedicarbamate includes a carbamate production process of producing toluenedicarbamate by reaction between toluenediamine, urea, and/or N-unsubstituted carbamic acid ester, and alcohol; and a benzoyleneurea reduction process of reducing a disubstituted benzoyleneurea and a derivative thereof to 10 mol or less relative to 100 mol of toluenedicarbamate, wherein the disubstituted benzoyleneurea is represented by formula (1) below and has a methyl group and an amino group:

URETHANE COMPOUND AND PROCESS FOR PRODUCTION THEREOF, AND ISOCYANATE AND PROCESS FOR PRODUCTION THEREOF

A method for producing urethane compounds includes allowing a primary amine, a urea and/or an N-unsubstituted carbamate, and an alcohol to react in the presence of a compound containing a noncoordinating anion and a metal atom as a catalyst.

URETHANE COMPOUND AND METHOD FOR PRODUCING THE SAME, AND ISOCYANATE AND METHOD FOR PRODUCING THE SAME

A method for producing urethane compounds includes allowing a primary amine, a urea and/or an N-unsubstituted carbamate, and an alcohol to react in the presence of a compound containing a noncoordinating anion and a metal atom as a catalyst.

METHOD FOR TREATMENT OF ISOCYANATE RESIDUE, AND METHOD FOR TREATMENT OF CARBONATE

A method for treating an isocyanate residue, which comprises carrying out a thermal decomposition reaction of a carbamate that is produced by the reaction among an amine, urea and/or an N-unsubstituted carbamic acid ester and an alcohol to produce a decomposition solution, separating an isocyanate and the alcohol from the decomposition solution to produce the isocyanate residue, and bringing the isocyanate residue into contact with high-pressure/high-temperature water to decompose the isocyanate residue into an amine; and a method for treating a carbonate, which comprises bringing the carbonate into contact with high-pressure/high-temperature water to decompose the carbonate into an alcohol.