74693-36-0Relevant academic research and scientific papers
Synthesis, spectral and antimicrobial evaluation of some novel 1-methyl-3-alkyl-2,6-diphenylpiperidin-4-one oxime carbonates
Sivakumar, Rajamanickam,Gokula Krishnan, Kannan,Thanikachalam, Venugopal
, p. 3195 - 3199 (2013/06/27)
Synthesis of some novel biologically active piperidin-4-one oxime carbonates from 1-methyl-3alkyl-2,6-diphenylpiperidin-4-one oximes and substituted chloroformates was carried out in the presence of potassium carbonate as base and tetrabutylammonium bromide (TBAB) as catalyst. The newly synthesized compounds were characterized by IR, 1H, 13C NMR and LC-mass spectra. Based on the 1H NMR analysis, all the compounds were found to adopt normal chair conformation with equatorial orientation of all the substituents. For all the synthesized compounds (5a-5l) antimicrobial activity has been tested against bacterial and fungal strains using Streptomycin and Amphotericin B as standards.
Convenient synthesis and NMR spectral studies of variously substituted N-methylpiperidin-4-one-O-benzyloximes
Parthiban, Paramasivam,Rani, Mannangatty,Kabilan, Senthamaraikannan
experimental part, p. 287 - 301 (2010/04/26)
A series of variously substituted N-methylpiperidin-4-one-O-benzyloximes were synthesized by three different methods. Among them, the direct conversion of 2,6-diarylpiperidin-4-ones into the corresponding oxime ethers (method A) was proved to be better than the other two methods in the sense of good yield, convenience, easy work-up and quick reaction time. All the synthesized compounds are characterized by IR, Mass and NMR (1H NMR, 13C NMR, 1H-1H COSY, 1H-13C COSY and HMBC) spectral studies. The conformational preference of the synthesized oxime ethers with/without alkyl and aryl substituents at C-3/C-5 and C-2/C-6 is discussed using the spectral data. The observed chemical shifts and coupling constants suggest that the synthesized oxime ethers adopt chair conformation with equatorial orientation of all the substituents, whereas 1-methyl-3-isopropyl-2, 6-diphenylpiperidin-4-one-O-benzyloxime also exists in boat conformation. Based on the NMR data, the effects of oximination on ring carbons and their associated protons and alkyl substituents are discussed. In addition, the effect of NMe group on the 2,6-diarylpiperidin-4-one-O-benzyloximes was also studied.
Reactivities of Variously Substituted 4-Heteracyclohexanones in the Formation of Oximes
Selvaraj, Kuppusamy,Nanjappan, Palaniappan,Ramalingam, Kondareddiar,Ramarajan, Krishnasamy
, p. 49 - 52 (2007/10/02)
The rates of oxime formation of 41 heterocyclic ketones have been measured at 5 deg C in aqueous alcoholic solution buffered at pH 6.85.The data indicate an overall second-order reaction, first order each in ketone and hydroxylamine.In all cases investiga
