74695-37-7Relevant academic research and scientific papers
Thienopyridines. Part 3. The Preparation of Some 6-Substituted 7-Hydroxythienopyridin-5(4H)-ones and Some Reactions of 7-Hydroxythienopyridin-5(4H)-one.
Barker, John M.,Huddleston, Patrick R.,Chadwick, Nigel,Keenan, Guy J.
, p. 113 - 126 (2007/10/02)
Reaction of 3-amino-2-alkoxycarbonylthiophens with compounds such as diethyl malonate or ethyl cyanoacetate produced amides, which were cyclised to 6-substituted-7-hydroxythienopyridin-5(4H)-ones by treatment with sodium hydride in dimethyl-formamide.Hydrolysis of the 6-ethoxycarbonyl derivative yielded 7-hydroxythienopyridin-5(4H)-one; some aspects of the chemistry of this substance, and of chloro-compounds derived from it, have been studied.
