747-99-9

Upstream product

• 446-53-7 2-fluorophenylmagnesium bromide 
• 635-21-2 5-chloroanthranilic acid 
• 897-82-5 5-chloro-2-tosylaminobenzoic acid 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1448808-89-6 5-chloro-3-(diiodomethyl)-3-(2-fluorophenyl)-1-tosylindolin-2-one 
• 1448531-86-9 1-(5-chloro-2-(tosylamino)phenyl)-1-(2-fluorophenyl)prop-2-yn-1-ol 
• 1448531-94-9 5-chloro-3-(2-fluorophenyl)-1-tosyl-1H-indole-2-carbaldehyde 

Relevant academic research and scientific papers

1-(2′-Anilinyl)prop-2-yn-1-ol rearrangement for oxindole synthesis

A synthetic method that relies on NIS (N-iodosuccinimide)-mediated cycloisomerization reactions of 1-(2′-anilinyl)prop-2-yn-1-ols to gem-3-(diiodomethyl)indolin-2-ones and 2-(iodomethylene)indolin-3-ones has been developed. The reactions were shown to be chemoselective, with secondary and tertiary alcoholic substrates exclusively giving the 3- and 2-oxindole products, respectively. In the case of the latter, the transformation features an unprecedented double 1,2-OH and 1,2-alkyl migration relay. Density functional theory (DFT) calculations based on proposed iodoaminocyclization species provide insight into this unique divergence in product selectivity. Copyright

Metal-free synthesis of 1H-indole-2-carbaldehydes by N-iodosuccinimide- mediated cyclization of 1-(2′-anilinyl)prop-2-yn-1-ols in water. A formal synthesis of (R)-calindol

A N-iodosuccinimide (NIS)-mediated method to prepare 1H-indole-2- carbaldehydes efficiently from cycloisomerization of 1-(2-aminophenyl)prop-2-yn- 1-ols is described. The reaction is operationally straightforward and accomplished in good to excellent yiel

Bis-aryl sulfonamides

Compounds are provided that act as potent antagonists of chemokine receptors. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of chemokine receptor-mediated diseases, and as controls in assays for the identification of chemokine antagonists.