897-82-5

Basic information

• Product Name: Benzoic acid, 5-chloro-2-[[(4-methylphenyl)sulfonyl]amino]-
• CAS NO: 897-82-5
• Molecular Formula: C14H12ClNO4S
• Molecular Weight: 325.773
• Mol File: 897-82-5.mol

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 5-chloro-2-[[(4-methylphenyl)sulfonyl]amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 5-chloro-2-[[(4-methylphenyl)sulfonyl]amino]-(897-82-5)
• EPA Substance Registry System: Benzoic acid, 5-chloro-2-[[(4-methylphenyl)sulfonyl]amino]-(897-82-5)

Safety Data

• Hazardous Substances Data: 897-82-5(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 635-21-2 5-chloroanthranilic acid 
• 1570135-11-3 5-chloro-N-(2-(4,5-dihydrooxazol-2-yl)phenyl)-2-(4-methylphenylsulfonamido)benzamide 

Downstream Products

• 837-58-1 2-amino-4'-chloro-5-chlorobenzophenone 
• 128832-47-3 2-tosylamino-5-chloro-2'-hydroxy-3',4'-dimethoxybenzophenone 
• 1448531-86-9 1-(5-chloro-2-(tosylamino)phenyl)-1-(2-fluorophenyl)prop-2-yn-1-ol 
• 1315477-43-0 1-(5-chloro-2-(tosylamino)phenyl)-1-phenylprop-2-yn-1-ol 
• 4873-59-0 2-tosylamido-5-chlorobenzophenone 
• 747-99-9 N-[4-Chloro-2-(2-fluoro-benzoyl)-phenyl]-4-methyl-benzenesulfonamide 
• 1448808-67-0 5-chloro-3-(diiodomethyl)-3-phenyl-1-tosylindolin-2-one 
• 1448808-89-6 5-chloro-3-(diiodomethyl)-3-(2-fluorophenyl)-1-tosylindolin-2-one 
• 1448531-94-9 5-chloro-3-(2-fluorophenyl)-1-tosyl-1H-indole-2-carbaldehyde 

Relevant articles and documents

Cu(II)-mediated C-H amidation and amination of arenes: Exceptional compatibility with heterocycles

A Cu(OAc)2-mediated C-H amidation and amination of arenes and heteroarenes has been developed using a readily removable directing group. A wide range of sulfonamides, amides, and anilines function as amine donors in this reaction. Heterocycles present in both reactants are tolerated, making this a broadly applicable method for the synthesis of a family of inhibitors including 2-benzamidobenzoic acids and N-phenylaminobenzoates.

1-(2′-Anilinyl)prop-2-yn-1-ol rearrangement for oxindole synthesis

A synthetic method that relies on NIS (N-iodosuccinimide)-mediated cycloisomerization reactions of 1-(2′-anilinyl)prop-2-yn-1-ols to gem-3-(diiodomethyl)indolin-2-ones and 2-(iodomethylene)indolin-3-ones has been developed. The reactions were shown to be chemoselective, with secondary and tertiary alcoholic substrates exclusively giving the 3- and 2-oxindole products, respectively. In the case of the latter, the transformation features an unprecedented double 1,2-OH and 1,2-alkyl migration relay. Density functional theory (DFT) calculations based on proposed iodoaminocyclization species provide insight into this unique divergence in product selectivity. Copyright

Metal-free synthesis of 1H-indole-2-carbaldehydes by N-iodosuccinimide- mediated cyclization of 1-(2′-anilinyl)prop-2-yn-1-ols in water. A formal synthesis of (R)-calindol

A N-iodosuccinimide (NIS)-mediated method to prepare 1H-indole-2- carbaldehydes efficiently from cycloisomerization of 1-(2-aminophenyl)prop-2-yn- 1-ols is described. The reaction is operationally straightforward and accomplished in good to excellent yiel