74708-96-6

Upstream product

• 6118-51-0 exo-3,6-epoxy-1,2,3,6-tetrahydrophthalic anhydride 
• 106-40-1 4-bromo-aniline 
• 110-00-9 furan 
• 108-31-6 maleic anhydride 

Downstream Products

• 74652-43-0 endo,endo-N-(p-bromophenyl)-1,8,9,10,11,11-hexachloro-3,6-epoxytricyclo<6.2.1.0^2,7>undec-9-ene-4,5-dicarboximide 

Relevant academic research and scientific papers

Synthesis of Isoxazole-Linked Norcantharidin Analogues of Substituted Chromones

Eighteen novel norcantharidin derivatives, which were substituted by chromone ring, were synthesized in a single step by the [3 + 2] 1,3-dipolar cycloaddition reaction with three oximes in the presence of chloramine-T when compared with the conventional method.

Synthesis of Pyrazole-linked Norcantharidin Analogues of Substituted Chromones

Eighteen novel pyrazole-linked norcantharidin derivatives substituted by chromone ring were synthesized in a single step by the [3+2] 1,3-dipolar cycloaddition reaction of norcantharidin derivatives of substituted aromatic amines with hydrazone in the presence of chloramine-T as compared to the conventional method.

Containing chromon structure-isoxazole Norcantharidin derivative and its preparation method and application

The invention discloses novel chromone structure containing isoxazole norcantharidin derivatives as well as a preparation method and an application thereof. The preparation method is characterized by introducing isoxazole rings to C5 and C6 in a norcantharidin structure by using a 1,3-dipolar cycloaddition method to react with chromone derivatives to import the chromone structures, thus synthesizing a series of totally six novel chromone structure containing isoxazole norcantharidin derivatives. The isoxazole norcantharidin derivatives are applied to synthesis of antitumor drugs and have broad application prospects.

Synthesis of high-Tg polymers via ROMP of oxanorbornene dicarboximides with halogen groups

This paper describes the synthesis of exo-N-phenyl-7-oxanorbornene-5, 6-dicarboximides with different substituents at para positions in the aromatic ring and their polymerization by ring-opening metathesis polymerization (ROMP) leading to high-Tg polymers. Exo-N-4-chlorophenyl-7- oxanorbornene-5, 6-dicarboximide (ClPhONDI, 3a), exo-N-4-bromophenyl-7-oxanorbornene-5, 6-dicarboximide (BrPhONDI, 3b), and exo-N-4-iodophenyl- 7-oxanorbornene-5, 6-dicarboximide (IPhONDI, 3c) monomers were synthesized. Polynorbornene dicarboximides were obtained via ROMP using a first-generation ruthenium alkylidene catalyst, Cl2(PCy3)2Ru(=CHPh). The resulting amorphous polymers with trans configuration of the double bonds were characterized by NMR, SEM, DSC, and GPC.

Norcantharidin analogues - Synthesis and evaluation of growth inhibition in a panel of selected tumor-cell lines

A series of norcantharidin (NCTD) analogues have been synthesized by [3+2]1,3-dipolar cycloaddition reaction of norcantharidin derivatives of substituted aromatic amines with four nitrile oximes. All analogues have been screened for their antiproliferative activity in vitro against a panel of tumor cell lines: KB, SGC-7901, HL60, Bel-7402, HO-8910, and ECA109, producing IC 50 values from 0.36 μmol/L to >100 μmol/L. Compound 9d showed potency for the treatment of hepatoma, with IC50 value to Bel-7402 cell line comparable to that of norcantharidin.

1,3-Dipolar cycloaddition reaction: Synthesis of novel 5,6- dehydronorcantharidin derivatives of substituted aromatic amines with potential antitumor activities

Twelve novel compounds were synthesized by the [3+2] 1,3-dipolar cycloaddition reaction of 5,6-dehydronorcantharidin derivatives of substituted aromatic amines with nitrile oxides. The structure and the configuration of all compounds were confirmed by 1H NMR, IR, MS, 1H- 1HCOSY, and NOESY spectral data. Their anti-tumor activities are under way.