7471-52-5Relevant academic research and scientific papers
Substitution of the phosphonic acid and hydroxamic acid functionalities of the DXR inhibitor FR900098: An attempt to improve the activity against Mycobacterium tuberculosis
Andaloussi, Mounir,Lindh, Martin,Bj?rkelid, Christofer,Suresh, Surisetti,Wieckowska, Anna,Iyer, Harini,Karlén, Anders,Larhed, Mats
scheme or table, p. 5403 - 5407 (2011/10/12)
Two series of FR900098/fosmidomycin analogs were synthesized and evaluated for MtDXR inhibition and Mycobacterium tuberculosis whole-cell activity. The design rationale of these compounds involved the exchange of either the phosphonic acid or the hydroxamic acid part for alternative acidic and metal-coordinating functionalities. The best inhibitors provided IC50 values in the micromolar range, with a best value of 41 μM.
Potential Pancreatic Imaging Agents. Tellurium-123m Labeled DL-α-Amino-γ-(phenyltelluro)butyric Acid
Knapp, Furn F.,Ambrose, Kathleen R.,Callahan, Alvin P.
, p. 794 - 797 (2007/10/02)
This report describes the first successful preparation of a 123mTe-labeled α-amino acid as a potential pancreatic imaging agent.Tellurium-123m labeled DL-α-amino-γ-(phenyltelluro)butyric acid was prepared by basic hydrolysis of the radiolabeled 5-β-(phen
123m Te-Labeled biochemicals and method of preparation
-
, (2008/06/13)
A novel class of 123m Te-labeled steroids and amino acids is provided by the method of reacting a 123m Te symmetric diorgano ditelluride with a hydride reducing agent and a source of alkali metal ions to form an alkali metal organo telluride. The alkali metal organo telluride is reacted with a primary halogenated steroidal side chain, amino acid, or amino acid precursor such as hydantoin. The novel compounds are useful as biological tracers and as organal imaging agents.
