74712-88-2

Upstream product

• 74712-86-0 Phosphoric acid 2-(2-chloro-4-nitro-phenyl)-ethyl ester (2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester; compound with triethyl-amine 
• 40733-27-5 3'-O-(t-butyldimethylsilyl)thymidine 
• 69395-15-9 2-(2-chloro-4-nitro-phenyl)-ethanol 
• 74706-79-9 Phosphoric acid 2-(2-chloro-4-nitro-phenyl)-ethyl ester 2,5-dichloro-phenyl ester (2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 
• 42926-80-7 5'-O-(4-monomethoxytrityl)-2'-deoxythymidine 

Relevant academic research and scientific papers

New improvements in oligonucleotide synthesis by use of the p-nitrophenylethyl phosphate blocking group and its deprotection by DBU or DBN

Phosphate protection in the phosphotriester approach is improved by the new, versatile p-nitrophenylethyl group due to its stability in the condensation step and its clean removal by DBU and DBN respectively.