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Upstream product

• 25726-04-9 phenylglyoxylyl chloride 
• 611-73-4 Benzoylformic acid 
• 4732-66-5 2-oxo-N,2-diphenylacetamide 
• 4410-33-7 N-phenyl-2-hydroxy-4-phenylacetamide 
• 74-88-4 methyl iodide 
• 7021-09-2 rac-methoxyphenylacetic acid 
• 62-53-3 aniline 
• 34713-98-9 2-methoxy-2-(phenyl)acetyl chloride 

Relevant academic research and scientific papers

Potassium Phosphate-Catalyzed Chemoselective Reduction of α-Keto Amides: Route to Synthesize Passerini Adducts and 3-Phenyloxindoles

A chemoselective reduction of α-keto amides to biologically important α-hydroxy amides (mandelamides) by polymethylhydrosiloxane (PMHS) using 5 mol% potassium phosphate (K3PO4) as catalyst has been developed. This transition metal-free protocol discloses excellent chemoselectivity for the ketone reduction of α-keto amides in the presence of other reducible functionalities like ketone, nitro, halides, nitrile and amide. Also, the chemoselectively reduced α-hydroxy amide has been derivatized to isocyanide-free Passerini adducts. The N-alkyl-α-hydroxy amides have been successfully converted to 3-phenyloxindole derivatives by treatment with methanesulfonyl cholride and triethylamine.

New boron(III)-catalyzed amide and ester condensation reactions

In 1996, we reported that benzeneboronic acids bearing electron-withdrawing groups at the meta- or para-position are highly effective catalysts for the amide condensation reaction in less-polar solvents. In this paper, we report that N-alkyl-4-boronopyridinium halides are more effective catalysts than the previous ones in more polar solvents. N-Alkyl-4-boronopyridinium halides are effective not only for amide condensation between equimolar mixtures of carboxylic acids and amines but also for the esterification of α-hydroxycarboxylic acids in alcohol solvents. Furthermore, perchlorocatecholborane is more effective than areneboronic acids for the amide condensation of sterically demanding carboxylic acids. In addition, Lewis acid-assisted Br?nsted acid (LBA), which is prepared from a 1:2 M mixture of boric acid and tetrachlorocatechol, is effective for the Ritter reaction from alcohols and nitriles to amides.

N-alkyl-4-boronopyridinium salts as thermally stable and reusable amide condensation catalysts

(Chemical Equation Presented) N-Alkyl-4-boronopyridinium salts are highly effective and reusable catalysts for the dehydrative amide condensation reaction between equimolar mixtures of carboxylic acids and amines. N- Alkylboronopyridinium salts are thermally stabilized in the order N-alkyl-2-boronopyridinium salt ? N-alkyl-3-boronopyridinium salt N-alkyl-4-boronopyridinium salt. Homogeneous catalysts, such as 4-borono-N-methylpyridinium iodide, are more effective in the presence of ionic liquid and can be recovered by extraction with ionic liquid. In contrast, heterogeneous catalysts, such as polystyrene-bound 4-boronopyridinium salts, are effective even in the absence of ionic liquid and can be recovered by filtration.

The Chemistry of 5-Oxodihydroisoxales. XI; The Photolysis of 3-Hydroxy-4-phenylisoxazol-5(2H)-ones (Phenyldisic Acids)

3-Hydroxy-2-methyl-4-phenylisoxazol-5(2H)-one, 3-hydroxy-2,4-diphenylisoxazol-5(2H)-one and phenyldisic acid have been photolysed at 254 nm in hydroxylic solvents.By comparision of the respective products with those obtained from 3-methoxy-4-phenylisoxazo