74721-29-2Relevant academic research and scientific papers
New Steroidal Heterocycles: The Synthesis and Structure of Androsteno-, Androstano-, and Androsteno-pyrazolopyrimidines
Bajwa, Joginder S.,Sykes, Peter J.
, p. 481 - 486 (1980)
The reaction of 3-aminopyrazole and its 4-cyano-derivative with 2-hydroxymethylene-3-oxo-steroids gave a mixture of angularly fused and linearly fused products, androst-2-eno- and androstano-pyrazolopyrimidines, respectively.However, the condensation of 3-amino-4-cyano-5-cyanomethylpyrazole with 2-hydroxymethyl-3-oxo-steroids gave only angularly fused products, namely, androst-2-enopyrazolopyrimidines.The reaction of 3-aminopyrazole and its derivatives with a 2-hydroxymethylene-Δ4-3-oxo-steroid and 16-hydroxymethylene-17-oxo-steroids also afforded only the angularly fused products, androst-2,4-dieno- and androst-16-eno-pyrazolopyrimidines, respectuvely.The structures of all these compounds were established by i.r., u.v., and 1H and 13C n.m.r. spectroscopy.
