747358-03-8

Basic information

• Product Name: C₁₀H₁₅NO₂
• Synonyms: C₁₀H₁₅NO₂
• CAS NO: 747358-03-8
• Molecular Weight: 181.235
• Mol File: 747358-03-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₀H₁₅NO₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₀H₁₅NO₂(747358-03-8)
• EPA Substance Registry System: C₁₀H₁₅NO₂(747358-03-8)

Safety Data

• Hazardous Substances Data: 747358-03-8(Hazardous Substances Data)

Upstream product

• 591-31-1 3-methoxy-benzaldehyde 
• 74-88-4 methyl iodide 

Downstream Products

• 59-42-7 Phenylephrin 

Relevant articles and documents

Method for synthesizing chiral alpha-amino alcohol compound

The invention discloses a method for synthesizing a chiral alpha-amino alcohol compound. The method comprises the following steps: sequentially adding an iron catalyst, a ligand, ketone, an organic solvent and silane into a reaction system at 20-30 DEG C in a nitrogen atmosphere, then stirring the obtained mixture, and carrying out column chromatography separation on the obtained product to obtain a product, namely chiral alpha-amino alcohol. According to the invention, the most high-yield iron catalyst in earth crust is used, and cheap silane (PMHS, 500 g/298 yuan) is adopted as a reducing agent, so the asymmetric reduction reaction of alpha-amino ketone can be efficiently achieved under mild conditions so as to obtain the high-yield optically-active chiral alpha-amino alcohol compound; and moreover, through the creative labor of the inventor, reaction yield can reach 99%, and meanwhile, the content of the target product in the generated reaction product is 99%.