7474-80-8Relevant articles and documents
Synthesis and antimalarial property of orally active phenoxazinium salts
Takasu, Kiyosei,Shimogama, Tsubasa,Satoh, Chie,Kaiser, Marcel,Brun, Reto,Ihara, Masataka
, p. 2281 - 2284 (2008/02/02)
Phenoxazinium salts were found to display good antimalarial efficacy in vivo against Plasmodium berghei. Several compounds provided 100% parasitemia clearance at a dose of 20-30 mg kg-1 x 4 days (ip) and good survival effects without obvious acute toxicity. They also showed excellent potency by oral administration. A preliminary pharmacokinetic study revealed that the oral availability of 1a was excellent.