74756-11-9Relevant academic research and scientific papers
Preparation method of (1S, 4R)-1-methyl-4-(1-methyl vinyl)-2-cyclohexene-1-alcohol
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Paragraph 0068-0070; 0074, (2021/01/15)
The invention discloses a preparation method of (1S, 4R)-1-methyl-4-(1-methyl vinyl)-2-cyclohexene-1-alcohol, which comprises the following steps: by using D-limonene as a raw material, carrying out double bond addition and hydroxyl protection to obtain an intermediate compound; and carrying out elimination reaction and continuing deprotection to finally prepare the product. The method has the advantages of two-step continuous reaction, short process route and few byproducts, the obtained product has high chiral selectivity, and the yield is up to 70% or above and is greatly improved comparedwith the existing process.
A trans - menthyl - 2, 8 - diene -1 - alcohol synthesis process
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Paragraph 0034; 0039-0040; 0043; 0068; 0072; 0073; 0077, (2019/05/21)
The invention belongs to the trans - menthyl - 2, 8 - diene - 1 - ol preparation technology field, in particular to a trans - menthyl - 2, 8 - diene - 1 - ol synthesis process. The synthesizing process comprises the following steps: (1) in order to limonene as raw materials, in order to lipase catalytic oxidation to obtain the 1, 2 - epoxy limonene; (2) the 1, 2 - epoxy limonene in the presence of sodium borohydride and diphenyl [...] open-loop formed limonene selenide; (3) the limonene selenide in under the action of the oxidizing agent forms the selenium oxide then undergo elimination reaction trans - menthyl - 2, 8 - diene - 1 - ol. The invention through the material and a prepared selective lipase catalyzed the situation that the 1, 2 - epoxy limonene, the need for complex purification process can increase the purity of the reaction intermediate, thereby improving the final product trans - menthyl - 2, 8 - diene - 1 - ol of chiral purity.
