22121-86-4

Basic information

• Product Name: ethyl 2-ethoxy acrylate
• Synonyms: ethyl 2-ethoxy acrylate;2-Ethoxy-acrylic acid ethyl ester
• CAS NO: 22121-86-4
• Molecular Formula: C₇H₁₂O₃
• Molecular Weight: 144.17
• Product Categories: Acids and Esters
• Mol File: 22121-86-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 178-180 °C(Press: 700 Torr)
• Appearance: /
• Density: 0.9956 g/cm3(Temp: 17.200009765625 °C)
• CAS DataBase Reference: ethyl 2-ethoxy acrylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-ethoxy acrylate(22121-86-4)
• EPA Substance Registry System: ethyl 2-ethoxy acrylate(22121-86-4)

Safety Data

• Hazardous Substances Data: 22121-86-4(Hazardous Substances Data)

Usage

General Description

Ethyl 2-ethoxy acrylate is a chemical compound commonly used in the production of coatings, adhesives, and sealants. It is a clear, colorless liquid with a faint, fruity odor and is highly flammable. Ethyl 2-ethoxy acrylate is a versatile monomer that can polymerize to form a variety of polymers with different properties, making it useful in a wide range of applications. It is also used as a solvent in various industrial processes and as a chemical intermediate in the production of other compounds. However, ethyl 2-ethoxy acrylate should be handled with care due to its potential health hazards, including skin and eye irritation, and its harmful effects if inhaled or ingested. Proper safety measures should be taken when working with this chemical.

Upstream product

• 64-17-5 ethanol 
• 87271-69-0 2-ethoxy-3-bromo-propionitrile 
• 7476-20-2 ethyl 2,2-diethoxypropionate 
• 50-00-0 formaldehyd 
• 34006-60-5 ethyl 2-chloro-2-ethoxyacetate 
• 1360565-56-5 (1,2-diethoxy-2-oxo-ethyl)diethylphosphonium chloride 
• 617-35-6 2-oxo-propionic acid ethyl ester 
• 858786-37-5 2-ethoxy-3-hydroxy-propionic acid ethyl ester 
• 127-08-2 potassium acetate 

Downstream Products

• 853787-25-4 2-ethoxy-1,1-diphenyl-allyl alcohol 
• 101170-80-3 1-ethoxy-3,4-dimethyl-cyclohex-3-enecarboxylic acid ethyl ester 
• 117373-40-7 2-ethoxy-3,4-dihydro-2H-pyran-3-carboxylic acid ethyl ester 
• 116922-16-8 ethyl α-ethoxy-2-cyanocinnamate 
• 116922-15-7 ethyl 2-acetylamino-α-ethoxycinnamate 
• 348-36-7 ethyl 5-fluoro-1H-indole-2-carboxylate 
• 3770-50-1 2-carbethoxyindole 
• 4792-67-0 5-chloro-indole-2-carboxylic acid ethyl ester 
• 16382-15-3 5-methyl-1H-indole-2-carboxylic acid ethyl ester 
• 27034-51-1 ethyl 6-chloro-1H-indole-2-carboxylate 
• 15050-04-1 6-methoxy-1H-indole-2-carboxylic acid ethyl ester 
• 105191-13-7 5-Cyano-1H-indole-2-carboxylic acid ethyl ester 

Relevant articles and documents

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A tandem "on-palladium" Heck-Jeffery amination route toward the synthesis of functionalized indole-2-carboxylates

A direct synthesis of functionalized indole-2-carboxylates involving a PdII-catalyzed annulation of ortho-iodoanilines onto a vinyl ether is described. The reaction mechanism is shown to be distinct from a stepwise Heck, intramolecular amination pathway, likely involving a tandem "on-palladium" Heck-Jeffery amination process incorporating a novel intramolecular amination step.

Intramolecular 4+3 cycloadditions, vinylthionium ions from allylic alcohols

Aldehyde 9 can be prepared from ethyl pyruvate in several steps. Treatment of 1 with various diene-containing Grignard reagents results in the formation of the corresponding allylic alcohol in good yield. Exposure of these alcohols to triflic anhydride results in the formation of 4+3 cycloadducts in good to excellent yields. Furan and simple butadiene trap the intermediate allylic cation efficiently in the formation of 5,7-fused ring systems. A tethered thiophene undergoes only intramolecular Friedel-Crafts alkylation.