7477-43-2

Upstream product

• 50342-01-3 quinolin-2-ylcarbonyl chloride 
• 106-47-8 4-chloro-aniline 
• 41374-66-7 methyl 2-[(4-chlorophenyl)amino]-2-oxoacetate 
• 91-63-4 2-methylquinoline 

Relevant academic research and scientific papers

A two-stage, three-stage aromatic amide compound synthesis method

The invention provides a synthetic method for forming binary and ternary aryl amide compounds by virtue of direct methyl functionalization. The method comprises the following steps: by taking a 2-methyl-N-heterocyclic aromatic hydrocarbon and an amine sou

Copper-catalyzed efficient direct amidation of 2-methylquinolines with amines

A novel Cu-catalyzed direct amidation of 2-methylquinolines with amines is described. This method afforded an efficient approach for the synthesis of biologically important aromatic amides from readily available coupling partners using molecular oxygen as the oxidant.

Copper catalysed direct amidation of methyl groups with N-H bonds

An efficient copper catalyzed direct aerobic oxidative amidation of methyl groups of azaarylmethanes with N-H bonds producing amides is successfully developed, which can produce primary, secondary and tertiary amides, including those with functional groups. This reaction represents a straightforward method for the preparation of amides from the readily available hydrocarbon starting materials.

A FACILE, CONVENIENT AND SELECTIVE HOMOLYTIC CARBAMOYLATION OF HETEROAROMATIC BASES

The oxidative decarboxylation of monoamides of oxalic acid provides carbamoyl radicals, which are useful for the selective carbamoylation of protonated heteroaromatic bases; this reaction represents the first general and selective method for the N-alkyl or N-arylcarbamoylation of heteroaromatic bases.Compared to alkoxycarbonylation, this reaction is much more effective and selective, owing to more favourable polar and enthalpic effects.The importance of the steric effects is also emphasized.