7477-50-1

Upstream product

• 5424-43-1 3-bromoveratrole 
• 107-30-2 chloromethyl methyl ether 
• 621-59-0 isovanillin 
• 2973-58-2 2-bromoisovanillin 
• 55171-60-3 2-bromo-3,4-dimethoxybenzylaldehyde 
• 72912-38-0 (2-bromo-3,4-dimethoxyphenyl)methanol 

Downstream Products

• 72912-39-1 (2-bromo-3,4-dimethoxyphenyl)acetonitrile 
• 128638-02-8 2-(2-bromo-3,4-dimethoxybenzyl)-2-(2-hydroxy-3-methoxyphenyl)-1,3-dithiane 
• 128690-97-1 2-(2-Benzyloxy-3-methoxy-phenyl)-2-(2-bromo-3,4-dimethoxy-benzyl)-[1,3]dithiane 
• 168776-00-9 2-(2-bromo-3,4-dimethoxybenzyl)-2-(2-methoxymethoxy-3,4-methylenedioxyphenyl)-1,3-dithiane 
• 1411714-30-1 C₃₂H₃₃NO₅ 
• 1411714-34-5 C₃₂H₂₉NO₄ 
• 1254068-24-0 N-(2,3-dimethoxyphenethyl)-2-[(2-(4-biphenyl)-3,4-dimethoxyphenyl)]acetamide 
• 1254068-68-2 C₃₂H₃₁NO₄ 
• 1254068-25-1 1-[2-(biphenyl-4-yl)-3,4-dimethoxybenzyl]-5,6-dimethoxyisoquinoline 
• 1254068-23-9 N-[2-[1-(2,3-dimethoxyphenyl)]-ethyl]2-bromo-3,4-dimethoxyphenylacetamide 
• 1411713-99-9 C₃₄H₃₀NO₄⁽¹⁺⁾ 
• 1411713-95-5 C₃₃H₂₈NO₄⁽¹⁺⁾ 
• 1254067-76-9 C₃₄H₃₀NO₄⁽¹⁺⁾ 
• 1254157-51-1 C₃₃H₂₈NO₄⁽¹⁺⁾ 

Relevant academic research and scientific papers

Antibacterial activity of substituted dibenzo[a,g]quinolizin-7-ium derivatives

Berberine is a substituted dibenzo[a,g]quinolizin-7-ium derivative whose modest antibiotic activity is derived from its disruptive impact on the function of the essential bacterial cell division protein FtsZ. The present study reveals that the presence of

ANTIMICROBIAL AGENTS

The invention provides a compound of formula (I): or a salt or prodrug thereof, wherein Y, W, Z, Z1, Z2, Z3, Z4, and R1- R12 have any of the values described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as antibacterial agents

Synthesis of phthalideisoquinoline and protoberberine alkaloids and indolo[2,1-α]isoquinolines in a divergent route involving palladium(0)- catalyzed carbonylation

6,7,3',4'-Alkoxy-substituted 1-(2'-bromobenzoyl)-3,4-dihydroisoquinoline methiodides 17 were treated with sodium borohydride in methanol or acetic acid to give erythro-1-(2'-bromo-α-hydroxybenzyl)-2-methyl-1,2,3,4- tetrahydroisoquinolines 19. Treatment of 17 with lithium aluminum hydride in tetrahydrofuran gave the threo-isomer 20 in preference to the erythro 19. On the basis of studies on palladium(0)-catalyzed carbonylation of 2-bromo-3,4- dimethoxybenzyl alcohol to 6,7-dimethoxyphthalide, amino alcohol 19 or 20 was treated with a catalytic amount of palladium(II) acetate and triphenylphosphine in an atmosphere of carbon monoxide in the presence of chlorotrimethylsilane and potassium carbonate in boiling toluene to give the corresponding erythro- or threo-types of phthalideisoquinoline alkaloids 1 or 2, respectively. One-pot cyclization of the erythro-amino alcohols 19 was achieved by heating in N,N-dimethylformamide containing potassium carbonate to give 2,3,8,9- or 2,3,9,10-alkoxy-substituted 5,6-dihydroindolo[2,1- α]isoquinolines 3, which have a unique tetracyclic skeleton characteristic of dibenzopyrrocoline alkaloids. Similarly, palladium-(0)-catalyzed carbonylation of 1-(2'-bromobenzyl)tetrahydroisoquinolines 21 in the presence of excess potassium carbonate was found to give 8-oxoberbines 22, which on reduction with lithium aluminum hydride can be converted to protoberberine alkaloids 4.