74770-02-8

Upstream product

• 104-94-9 4-methoxy-aniline 
• 144-62-7 oxalic acid 
• 41010-68-8 2-(4-methoxyphenyl)amino-3-amino-pyridine 
• 5470-18-8 2-Chloro-3-nitropyridine 

Downstream Products

• 1359964-24-1 2-hydrazinyl-4-(4-methoxyphenyl)pyrido[2,3-b]pyrazin-3(4H)-one 
• 1359964-77-4 2-(2-(2-hydroxybenzylidene)hydrazinyl)-4-(4-methoxyphenyl)pyrido[2,3-b]pyrazin-3(4H)-one 
• 1359964-81-0 2-(2-(4-chloro-2-hydroxybenzylidene)hydrazinyl)-4-(4-methoxyphenyl)pyrido[2,3-b]pyrazin-3(4H)-one 
• 1359964-84-3 2-(2-(3-allyl-2-hydroxybenzylidene)hydrazinyl)-4-(4-methoxyphenyl)pyrido[2,3-b]pyrazin-3(4H)-one 
• 1359964-88-7 2-(2-(3-allyl-2-hydroxy-5-methylbenzylidene)hydrazinyl)-4-(4-methoxyphenyl)pyrido[2,3-b]pyrazin-3(4H)-one 
• 1359964-92-3 2-(2-(3-allyl-5-tert-butyl-2-hydroxybenzylidene)hydrazinyl)-4-(4-methoxyphenyl)pyrido[2,3-b]pyrazin-3(4H)-one 
• 1359964-95-6 2-(2-(2-hydroxy-3-(2-methylallyl)benzylidene)hydrazinyl)-4-(4-methoxyphenyl)pyrido[2,3-b]pyrazin-3(4H)-one 
• 1359964-98-9 2-(2-(2,4-dihydroxybenzylidene)hydrazinyl)-4-(4-methoxyphenyl)pyrido[2,3-b]pyrazin-3(4H)-one 
• 1359965-01-7 4-(4-methoxyphenyl)-2-(2-(2,3,4-trihydroxybenzylidene)hydrazinyl)pyrido[2,3-b]pyrazin-3(4H)-one 

Relevant academic research and scientific papers

Synthesis and cytotoxicity studies of novel 2-hydrazonylpyrido[2,3-b] pyrazin-3(4H)-ones

In an attempt to develop potent antitumor agents, a series of novel 2-hydrazonylpyrido[2,3-b]pyrazin-3(4H)-one derivatives were designed and synthesized. All the prepared compounds were screened for their cytotoxic activities against A549, MDA-MB-231 and HT-29 cell lines in vitro. Pharmacological data indicated that five of the target compounds showed cytotoxicity against A549 cell line below a concentration of 1 μM. Compound 15g was the most potent one with IC50 values of 0.19, 2.11 and 2.15 μM against A549, MDA-MB-231 and HT29 cell lines, respectively. A series of 2-hydrazonylpyrido[2,3-b]pyrazin-3(4H)-one derivatives was designed and synthesized. Preliminary structure-activity relationships suggested that compounds with 4-methoxyphenyl or 4-(trifluoromethoxy)phenyl groups on the N-4 position were generally more potent than those with an unsubstituted phenyl group. Copyright