74772-93-3Relevant academic research and scientific papers
Optimization of the reduction of a 5-benzylidenethiazolidine-2,4-dione derivative supported by the reaction response surface analysis: Synthesis of pioglitazone hydrochloride
Les, Andrzej,Pucko, Wieslaw,Szelejewski, Wieslaw
, p. 157 - 162 (2004)
A reaction response surface analysis was applied to a series of experiments carried out under various conditions (temperature, time, amount of a catalyst and reduction reagents, purification of the substrate). Significant improvements were made in the C=C bond reduction in the benzylidene- thiazolidinedione intermediate in the synthesis of pioglitazone hydrochloride.
