7479-16-5

Usage

Chemical structure

Contains a benzimidazole ring with a chlorine atom attached and a pentitol group

Class

Belongs to the class of benzimidazole derivatives

Pharmacological activities

Known for their diverse pharmacological activities

Anti-fungal properties

Benzimidazole derivatives have been studied for their antifungal properties

Antiviral properties

Benzimidazole derivatives have been studied for their antiviral properties

Anticancer properties

Benzimidazole derivatives have been studied for their anticancer properties

Pharmaceutical synthesis

Used as intermediates in the synthesis of various pharmaceutical compounds

Further research

The specific properties and potential uses of 1-C-(6-chloro-1H-benzimidazol-2-yl)pentitol would require further research and investigation.

Upstream product

• 642-99-9 mannonic acid 
• 95-83-0 4-Chloro-1,2-phenylenediamine 
• 10030-80-5 L-mannose 
• 526-95-4 gluconic acid 
• 921-60-8 L-glucose 
• 133-42-6 D-galactonic acid 
• 15572-79-9 aldehydo-L-Galactose 
• 59-23-4 D-Galactose 
• 57803-83-5 4-chloro-o-phenylenediamine dihydrochloride 
• 1198-69-2 D-glucono-1,4-lactone 

Relevant academic research and scientific papers

Studies on saccharide benzimidazoles: 2-(β-D-gulofuranosyl)benzimidazole and 2-(β-D-glucofuranosyl)benzimidazole C-nucleoside analogs; synthesis, anomeric configuration and antifouling potency

A series of acyclic 2-(D-gulo-) and 2-(D-gluco-)benzimidazole C-nucloside analogs have been prepared by condensation of o-phenylenediamine dihydrochloride derivatives with D-gulonic acid-γ-lactone and D-gluconic acid-γ-lactone, separately. Acid catalyzed dehydrative cyclization of the acyclic benzimidazole C-nucleoside afforded the corresponding 2-(β-D-gulo-) and 2-(β-D-gluco-)furanosyl benzimidazole C-nucleoside analogs. The structure and the anomeric configuration of C-nucleoside analogs obtained were determined by periodate oxidation, 1H NMR, UV and circular dichroism (CD) spectroscopy. The antifouling property of C-nucleoside analogs has been studied using antibacterial biofilm test. 2-(D-gulo-) and 2-(D-gluco-)benzimidazole analogs were useful for inhibiting marine bacterial growth and did not cause any bad effect to the surrounding seawater.

COMPOUNDS AND METHODS FOR ANALYSIS AND SYNTHESIS OF SACCHARIDE COMPOUNDS

Provided is an isotope-labelled compound having a general formula IIa′, S-Y′-BIM, wherein S is a sugar moiety, Y′ is an isotope-containing sensor moiety and BIM is a benzimidazole. The compound may be used as an agent for saccharide analysis by magnetic resonance spectroscopy (NMR). A new glycan sequencing method and a glycoprotein synthesis method by using these compounds are also provided.

Iodine promoted simple synthesis of benzimidazole acyclonucleosides

A novel one-pot ecofriendly synthesis of 2,5,6-trisubstituted- 1H-benzimidazole nucleoside derivatives have been accomplished stepwise. i.e. substituted o-phenylenediamine and aldoses using iodine as an oxidant or promoter in acetic solution at room temperature. A practical method has been developed for conversion of unprotected and unmodified aldoses to aldobenzimidazoles.