921-60-8Relevant academic research and scientific papers
A new sesquiterpenoid glycoside from Saussurea involucrata
Qi, Shizhou,Yang, Yiren,Xian, Xiaoyan,Li, Xianzhe,Gao, Huiyuan
, p. 943 - 949 (2020)
Saussurea involucrata, known for the abundant bioactive components, is a precious traditional Chinese medicine. In this study, a novel guaiane sesquiterpenoid glycoside named (1R, 5R, 6R, 7R, 8S, 11S)-11, 13-dihydrodehydrocostuslactone-8-O-6'-2''(E)-butenoyl-β-D-glucopyranoside (1), together with seven known compounds (2–8) were isolated from the dried aerial part of S. involucrata. Their structures were elucidated by spectroscopic and physico-chemical analyses. The antioxidant and anti-inflammatory activities of compound 1 were investigated. And compound 1 showed weak radical scavenging activity and low inhibitory activity on nitric oxide (NO) production.
Porous structured CuO-CeO2 nanospheres for the direct oxidation of cellobiose and glucose to gluconic acid
Amaniampong, Prince Nana,Trinh, Quang Thang,Li, Kaixin,Mushrif, Samir H.,Hao, Yu,Yang, Yanhui
, p. 172 - 182 (2018)
Porous-structured CuO-CeO2 nanospheres were synthesized using a hydrothermal method and were tested as catalysts for the direct oxidation of cellobiose to gluconic acid. Catalytic reaction along with catalyst characterization results and 18O-oxygen isotope labeled experiments revealed that the surface lattice oxygen of CuO in CuO-CeO2 nanospheres was consumed during the oxidation of cellobiose. This provides a direct evidence of our previous work (Amaniampong et al., Angew. Chem. Int. Ed. 54 (2015) 8928–8933). Characterization results further suggested that the lattice oxygen in CeO2 did not participate in the oxidation; nonetheless, the addition of CeO2 to CuO enhanced the surface area of the catalyst composite which was crucial for the reaction. The spent catalyst upon re-oxidation regained its activity. In addition, isotope labeled deuterium oxide (D2O) experiments suggested that hydrogen exchange between the solvent and the substrate (glucose) are not involved in the mechanistic formation of gluconic acid and confirmed the solvent had no direct influence in the formation of gluconic acid.
Three new compounds from the twigs and leaves of Nageia fleuryi Hickel
Chen, Lu-Zhou,Liu, Yu-Nan,Lou, Hong-Xiang,Ren, Dong-Mei,Shen, Tao,Wang, Xiao-Ning,Xiang, Lan,Xu, Jia-Xin,Yang, Hu
supporting information, (2022/03/31)
Two new diterpenoids, 12,15-di-O-acetylhypargenin B (1) and taiwanin F-12-O-β-D-glucopyranoside (2), one new monoterpenoid, (S)-7-methyl-3-methyleneoct-6-ene-1,2-diyl diacetate (3), together with eight known compounds (4?11), were obtained from the twigs
Isolation, structural elucidation and molecular docking studies against SARS-CoV-2 main protease of new stigmastane-type steroidal glucosides isolated from the whole plants of Vernonia gratiosa
Anh, Hoang Le Tuan,Anh, Le Tuan,Lee, Ki Yong,Phong, Nguyen Viet,Quang Minh, Bui,Trang, Nguyen Minh,Trung, Nguyen Quang,Van Cong, Pham,Van Dan, Nguyen,Viet Duc, Ngo,Vinh, Le Ba
supporting information, (2022/02/22)
Phytochemical investigation of the whole plants of Vernonia gratiosa Hance. led in the isolation and identification of two new stigmastane-type steroidal glucosides (1–2), namely vernogratiosides A (1), and B (2). Their chemical structures were fully elucidated based on 1 D/2D NMR spectroscopic, HR-ESI-MS data analyses, and by producing derivatives by chemical reactions. The binding potential of the isolated compounds to replicase protein ? main protease of SARS-CoV-2 were examined using the molecular docking simulations. Our results show that the isolated steroidal glucosides (1–2) bind to the substrate‐binding site of SARS-CoV-2 main protease with binding affinities of ?7.2 and ?7.6 kcal/mol, respectively, as well as binding abilities equivalent to N3 inhibitor that has already been reported (–7.5 kcal/mol).
Phenolic glycosides and flavonoids with antioxidant and anticancer activities from Desmodium caudatum
Xu, Qian-Nan,Zhu, Dan,Wang, Guang-Hui,Lin, Ting,Sun, Cui-Ling,Ding, Rong,Tian, Wen-Jing,Chen, Hai-Feng
, p. 4534 - 4541 (2020/03/23)
Descaudatine A (1), an undescribed phenolic glycoside, along with a known analogue (2) and ten flavonoids (3-12), were isolated from the whole plant of Desmodium caudatum. Compounds 1 and 4 exhibited potent antioxidant activities with the IC50 of 58.59 μM and 31.31 μM, respectively, which were approached to that of the positive control Vitamin C (IC50 = 46.32 μM). Meanwhile, 12 showed moderate antioxidant activity with the IC50 of 173.9 μM. Besides, compounds 3 and 6 inhibited the proliferation of HeLa cells with IC50 values of 56.14 μM and 69.04 μM, respectively. Further studies indicated that 3 and 6 could dose-dependently induce PARP cleavage and might trigger caspase-3, 8, 9 activation to induce apoptosis. RXRα is an ideal anticancer target of nuclear receptor. The reporter gene assay of RXRα indicated that 3 and 6 could inhibited the 9-cis-RA induced RXRα transcription in a concentration-dependent manner.
Orthogonal Active-Site Labels for Mixed-Linkage endo-β-Glucanases
Jain, Namrata,Tamura, Kazune,Déjean, Guillaume,Van Petegem, Filip,Brumer, Harry
, p. 1968 - 1984 (2021/05/26)
Small molecule irreversible inhibitors are valuable tools for determining catalytically important active-site residues and revealing key details of the specificity, structure, and function of glycoside hydrolases (GHs). β-glucans that contain backbone β(1,3) linkages are widespread in nature, e.g., mixed-linkage β(1,3)/β(1,4)-glucans in the cell walls of higher plants and β(1,3)glucans in yeasts and algae. Commensurate with this ubiquity, a large diversity of mixed-linkage endoglucanases (MLGases, EC 3.2.1.73) and endo-β(1,3)-glucanases (laminarinases, EC 3.2.1.39 and EC 3.2.1.6) have evolved to specifically hydrolyze these polysaccharides, respectively, in environmental niches including the human gut. To facilitate biochemical and structural analysis of these GHs, with a focus on MLGases, we present here the facile chemo-enzymatic synthesis of a library of active-site-directed enzyme inhibitors based on mixed-linkage oligosaccharide scaffolds and N-bromoacetylglycosylamine or 2-fluoro-2-deoxyglycoside warheads. The effectiveness and irreversibility of these inhibitors were tested with exemplar MLGases and an endo-β(1,3)-glucanase. Notably, determination of inhibitor-bound crystal structures of a human-gut microbial MLGase from Glycoside Hydrolase Family 16 revealed.
Anti-inflammatory active components of the roots of Datura metel
Qin, Ze,Zhang, Jin,Chen, Liang,Liu, Shu-Xiang,Zhao, Hai-Feng,Mao, Hui-Min,Zhang, Hong-Yang,Li, De-Fang
, p. 392 - 398 (2020/03/30)
One new phenolic glycoside, methyl 3,4-dihydroxyphenylacetate-4-O-[2-O-β-D-apisoyl-6-O-(2-hydroxybenzoyl)]-β-D-glucopyranoside (1), together with 10 known compounds (2–11), were isolated from the roots of Datura metel. The structures of these compounds we
A new triterpenoid and a new flavonoid glycoside isolated from Bupleurum marginatum and their anti-inflammatory activity
Lei, Zhiqiang,Zou, Guoming,Gao, Ying,Yao, Yuqiao,Peng, Caiying,Shu, Jicheng,Yang, Ming
supporting information, p. 3492 - 3498 (2019/03/26)
This study to investigate chemical constituents from the aerial of Bupleurum marginatum led to the isolation of a new trierpenoid and a new flavonoid, namely 3β-hydroxy-cycloart-24-en-26-acetyloxy (1), and 3, 3′, 5′-trimethoxyl-myricetin 7-O-β-D–glucopyranoside (2) along with eight known compounds (3–10). Their structures were established by spectral data analyses (MS, 1D and 2D NMR), as well as by comparison of spectral data with those of the related known compounds. The 24-en-lanostane type triterpenoid with a cyclopropane ring (1 and 3) was firstly reported from this specie, which might be chemotaxonomic markers of this specie. In addition, compounds 1 and 2 were examined for their anti-inflammatory activity. Compounds 1 and 2 inhibited the NF κB induction by 60.61% and 24.30%.
Method for preparing lactic acid through catalytically converting carbohydrate
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Paragraph 0029-0040, (2020/11/01)
The invention relates to a method for preparing lactic acid through catalytically converting carbohydrate, and in particular, relates to a process for preparing lactic acid by catalytically convertingcarbohydrate under hydrothermal conditions. The method disclosed by the invention is characterized by specifically comprising the following steps: 1) adding carbohydrate and a catalyst into a closedhigh-pressure reaction kettle, and then adding pure water for mixing; 2) introducing nitrogen into the high-pressure reaction kettle to discharge air, introducing nitrogen of 2 MPa, stirring and heating to 160-300 DEG C, and carrying out reaction for 10-120 minutes; 3) putting the high-pressure reaction kettle in an ice-water bath, and cooling to room temperature; and 4) filtering the solution through a microporous filtering membrane to obtain the target product. The method can realize high conversion rate of carbohydrate and high yield of lactic acid, and has the advantages of less catalyst consumption, good circularity, small corrosion to reaction equipment and the like.
Chemical constituents of Bergenia crassifolia roots and their growth inhibitory activity against Babesia bovis and B. bigemina
Banzragchgarav, Orkhon,Murata, Toshihiro,Tuvshintulga, Bumduuren,Suganuma, Keisuke,Igarashi, Ikuo,Inoue, Noboru,Batkhuu, Javzan,Sasaki, Kenroh
, p. 79 - 83 (2018/11/25)
Bergenia crassifolia is a tea plant from in Northeast Asia, and it used to be a traditional medicine in Asian countries. From the roots of this plant, two new compounds, (2R,3S)-3-O-p-hydroxybenzoyl-5-O-galloylcatechin and 6-O-(3′′-O-methylgalloyl) arbutin, were isolated together with 20 known flavonoids, including catechins, kaemferols, arbutin derivatives, and bergenin derivatives. Their chemical structures were elucidated on the basis of spectroscopic data analyses. The anti-babesial activities of the isolated compounds were estimated using in vitro tests against Babesia bigemina and B. bovis, which are the most prevalent species associated with bovine babesiosis. The compounds with galloyl groups showed moderate growth-inhibition effects on B. bovis (IC50 0.80–10.3 μg/mL) and B. bigemina (IC50 5.69–8.60 μg/mL).
