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Usage

Uses

Used in Pharmaceutical Industry:
5-oxo-11,12-dihydrodibenzo[c,g][1,2]diazocin-5-ium-6(5H)-olate is used as a medication for the treatment of migraines and cluster headaches. It functions by binding to serotonin receptors in the brain, which helps to alleviate the symptoms of these conditions.
Used in Migraine Treatment:
Almotriptan is used as an acute migraine treatment, where it narrows the blood vessels in the brain, providing relief from migraine symptoms. It is often prescribed as a second-line treatment for acute migraine attacks due to its effectiveness in reducing the severity and duration of migraine episodes.
Used in Cluster Headache Management:
In addition to migraines, almotriptan is also used for the management of cluster headaches. Its action in binding to serotonin receptors helps to mitigate the intense pain associated with cluster headaches, offering a targeted approach to this specific type of headache.
Used in Various Formulations:
Almotriptan is available in different formulations, including oral tablets and orally disintegrating tablets, catering to the diverse needs of patients and ensuring ease of administration during acute episodes of migraines and cluster headaches.

Upstream product

• 16968-19-7 2,2'-dinitrobibenzyl 
• 40754-26-5 5,6-dihydrodibenzo-1,2-diazocine N-oxide 
• 23308-83-0 (2-nitrobenzyl)triphenylphosphonium bromide 
• 552-89-6 2-nitro-benzaldehyde 
• 34124-14-6 2,2'-ethylenedianiline 

Relevant academic research and scientific papers

Synthesis and spectroscopic characterization study of some cyclic-azodioxides

New compounds of cyclic-azodioxides have been prepared by oxidation of the corresponding diamines with sodium tungstate and hydrogen peroxide in a mixed ethanol/water solvent. Spectroscopic techniques, including IR, UV, 1H NMR, and 13C NMR, and CHN analysis were used to identify the products. In solution, the azodioxides were found to be in equilibrium with the corresponding dinitroso compounds. The IR values of the synthesised compounds are in agreement with the theoretical IR spectra. The Japan Institute of Heterocyclic Chemistry.

POLYCYCLIC DIAZODIOXIDE-BASED BCL-2 PROTEIN ANTAGONIST

Compounds of Formula 8 are provided: A and B are each independently selected from the group consisting of -NO-, -SO-, and - NR9-. C is a single bond or a double bond. D is selected from the group consisting of single bond, E is selected from th

Cyclic Azo Dioxides. Synthesis and Properties of Bis(o-nitrosobenzyl) Derivatives

Several cyclic azo dioxides have been prepared by oxidation of the corresponding diamines with sodium tungstate-hydrogen peroxide in ethanol-water: 4 (related to o,o'-dinitrosobibenzyl), 8 (related to bis(o-nitrosobenzyl)ether), 14 (related to bis(o-nitrosobenzyl)amine), 13 (the trifluoroacetate salt of 14), 12a and 12b (the N-carbomethoxy and N-carbo-tert-butoxy derivatives of 14).In solution the azo dioxides are in equilibrium (Ke) with the corresponding dinitroso forms: Ke increases with decreasing polarity of solvent and with increasing temperature.For azo dioxide 4 in dioxane at 25 deg C Ke = 0.18, Δ H0 = 7.09 +/- 0.47 kcal mol-1, and Δ S0 = 20.4 cal mol-1 deg-1.The azo dioxides decompose at elevated temperatures (>100 deg C); azo dioxide 14 is converted to 2-(o-nitrosobenzyl)indazole (15) in refluxing methylene chloride.