748080-29-7

Upstream product

• 91-66-7 N,N-diethylaniline 
• 911358-03-7 2-(bis(4-(diethylamino)phenyl)methyl)benzene-1,4-disulfonic acid 
• 89-98-5 2-chloro-benzaldehyde 
• 42481-01-6 4-chloro-3-formylbenzenesulfonic acid sodium salt 

Relevant academic research and scientific papers

METHOD FOR THE PREPARATION OF DIARLYMETHANE DYES AND TRIARYLMETHANE DYES INCLUDING ISOSULFAN BLUE

Disclosed herein is a method for the preparation of diarylmethane dyes and triarylmethane dyes, such as Isosulfan Blue, using electrochemistry. Further disclosed is Isosulfan Blue prepared from a process employing electrochemistry, compositions comprising the same, and use of the prepared Isosulfan Blue as an imaging agent.

METHOD FOR PREPARATION OF ISOSULFAN BLUE

Provided is a method of preparing isosulfan blue.

PROCESS FOR PREPARATION OF ISOSULFAN BLUE

A process for the preparation of isosulfan blue (Active Pharmaceutical Ingredient) is provided. A process is also provided for preparation of the intermediate, 2-chlorobenzaldehyde-5-sulfonic acid, sodium salt of formula (2), used in the preparation thereof and a procedure for the isolation of benzaldehyde-2,5-disulfonic acid, di-sodium salt of the formula (3). Also provided is a process for the preparation of an isoleuco acid of formula (4), which upon mild oxidation gives rise to isosulfan blue of pharmaceutical grade which can be used for preparation of pharmaceutical formulations. The isolation and purification procedures provided in the process provide substantially pure isosulfan blue with HPLC purity 99.5% or greater.