911358-03-7

Upstream product

• 89-98-5 2-chloro-benzaldehyde 
• 60767-69-3 4-chloro-3-formylbenzenesulfonic acid 
• 42481-01-6 4-chloro-3-formylbenzenesulfonic acid sodium salt 
• 91-66-7 N,N-diethylaniline 

Downstream Products

• 748080-29-7 isosulfan blue 
• 748080-29-7 isosulfan blue acid 

Relevant academic research and scientific papers

METHOD FOR THE PREPARATION OF DIARLYMETHANE DYES AND TRIARYLMETHANE DYES INCLUDING ISOSULFAN BLUE

Disclosed herein is a method for the preparation of diarylmethane dyes and triarylmethane dyes, such as Isosulfan Blue, using electrochemistry. Further disclosed is Isosulfan Blue prepared from a process employing electrochemistry, compositions comprising the same, and use of the prepared Isosulfan Blue as an imaging agent.

ISOSULFAN BLUE, ITS CRYSTALLINE FORM AND PROCESS FOR PREPARATION THEREOF

The invention relates to an improved process for the preparation N-[4-[[4-(diethyl amino) phenyl] (2,5-disulfophenyl)methylene]-2,5-cyclohexadien-1-ylidene]-N- ethylethanaminium inner salt sodium salt (Isosulfan blue) of formula I. The invention also relates to highly pure novel crystalline form of Isosulfan blue (I) hydrate and its process for the preparation thereof. The invention also relates to an improved process for the preparation of Isosulfan blue sodium hydrate having not more than 0.2% of desethyl impurity of formula A.

AN IMPROVED PROCESS FOR THE PREPARATION OF ISOSULFAN BLUE

The present invention relates to process for preparation of Isosulfan blue (Formula I) substantially free from desethyl impurity. (I)

PROCESS FOR PREPARATION OF ISOSULFAN BLUE

A process for the preparation of isosulfan blue (Active Pharmaceutical Ingredient) is provided. A process is also provided for preparation of the intermediate, 2-chlorobenzaldehyde-5-sulfonic acid, sodium salt of formula (2), used in the preparation thereof and a procedure for the isolation of benzaldehyde-2,5-disulfonic acid, di-sodium salt of the formula (3). Also provided is a process for the preparation of an isoleuco acid of formula (4), which upon mild oxidation gives rise to isosulfan blue of pharmaceutical grade which can be used for preparation of pharmaceutical formulations. The isolation and purification procedures provided in the process provide substantially pure isosulfan blue with HPLC purity 99.5% or greater.