74813-72-2Relevant academic research and scientific papers
Syntheses of L-Kynurenine Peptides Conducted Without Masking the Side-Chain Amino Group
Stewart, Frederick H. C.
, p. 633 - 640 (2007/10/02)
Various free L-kynurenine peptides, including an analogue of the opiate agonist leucine-enkephalin, have been synthesized by using the Nα-t-butoxycarbonyl derivative of L-kynurenine as a key precursor.By selecting appropriate mild conventional coupling procedures it was possible to carry out the synthetic operations without having to mask the side-chain amino group in any way, but intramolecular acylation with formation of a seven-membered lactam could be demonstrated under more vigorous conditions.
