748183-56-4Relevant academic research and scientific papers
Novel benzo[ b ]thiophene derivatives as new potential antidepressants with rapid onset of action
Berrade, Luis,Aisa, Bárbara,Ramirez, María J.,Galiano, Silvia,Guccione, Salvatore,Moltzau, Lise Román,Levy, Finn Olav,Nicoletti, Ferdinando,Battaglia, Giuseppe,Molinaro, Gemma,Aldana, Ignacio,Monge, Antonio,Perez-Silanes, Silvia
supporting information; experimental part, p. 3086 - 3090 (2011/07/07)
We report benzo[b]thiophene derivatives synthesized according to a dual strategy. 8j, 9c, and 9e with affinity values toward 5-HT7R and 5-HTT were selected to probe their antidepressant activity in vivo using the forced swimming text (FST). The results showed significant antidepressant activity after chronic treatment. 9c was effective in reducing the immobility time in FST even after acute treatment. These findings identify these compounds as a new class of antidepressants with a rapid onset of action.
5-Cyclic amine-3-arylsulfonylindazoles as novel 5-HT6 receptor antagonists
Haydar, Simon N.,Yun, Heedong,Andrae, Patrick M.,Mattes, James,Zhang, Jean,Kramer, Angela,Smith, Deborah L.,Huselton, Christine,Graf, Radka,Aschmies, Suzan,Schechter, Lee E.,Comery, Thomas A.,Robichaud, Albert J.
supporting information; scheme or table, p. 2521 - 2527 (2010/08/22)
Novel 5-cyclic amine-3-arylsulfonylindazoles were prepared, and several analogues within this class have been identified as high-affinity 5-HT 6 receptor ligands with improved pharmacokinetic and pharmacological properties. One selected example, 18b, showed good brain penetrability and a generally favorable pharmacokinetic profile with procognitive efficacy in the rat novel object recognition assay. The synthesis and structure-activity relationship of this potent class are discussed.
IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION
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Page/Page column 106, (2010/02/13)
Compounds of the formula (I), wherein variable groups are as defined within and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described are processes for their preparation and their use as medicaments, particularly medicaments for producing a cell cycle inhibitory (anti cell proliferation) effect in a warm blooded animal, such as man.
Substituted N-aryl heterocycles, process for their preparation and their use as medicaments
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, (2008/06/13)
The invention relates to substituted N-aryl heterocycles and to the physiologically tolerated salts and physiologically functional derivatives thereof. Compounds of the formula I in which the radicals have the stated meanings, the N-oxides and the physiologically tolerated salts thereof and process for the preparation thereof are described. The compounds are suitable for example as anorectic agents.
