74819-18-4

Upstream product

• 5157-08-4 3-methyl-4,5-dihydro-6-oxopyridazine 
• 104-87-0 4-methyl-benzaldehyde 
• 74819-13-9 3-chloro-6-methyl-4-(4-methylbenzyl)pyridazine 
• 100-52-7 benzaldehyde 
• 624-45-3 levulinic acid methyl ester 

Downstream Products

• 1359817-88-1 3-(4-isopropoxyphenylamino)-6-methyl-4-(4-methylbenzyl)pyridazine 
• 74826-00-9 Bis<6-methyl-4-(p-methylbenzyl)-3-pyridazinyl> Disulphide 
• 74819-33-3 2-(2-Carboxyethyl)-6-methyl-4-(p-methylbenzyl)pyridazin-3(2H)-one 
• 74819-23-1 3-Ethylthio-4-(p-methylbenzyl)-6-methylpyridazine 
• 74819-21-9 6-Methyl-4-(4-methyl-benzyl)-3-methylsulfanyl-pyridazine 
• 75256-54-1 4-p-tolylmethyl-2,6-dimethylpyridazin-3(2H)-one 
• 74819-31-1 3-[3-Methyl-5-(4-methyl-benzyl)-6-oxo-6H-pyridazin-1-yl]-propionitrile 
• 74819-13-9 3-chloro-6-methyl-4-(4-methylbenzyl)pyridazine 
• 74819-16-2 3-Mercapto-4-(p-methylbenzyl)-6-methylpyridazine 

Relevant academic research and scientific papers

Heterocyclic derivative and pharmaceutical composition comprising the same

The present invention provides novel compounds having a P2X3 and/or P2X2/3 receptor antagonistic effect. A pharmaceutical composition having a P2X3 and/or P2X2/3 receptor antagonistic effect comprising a compoun

NOVEL HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING SAME

The present invention provides novel compounds having a P2X3 and/or P2X2/3 receptor antagonistic effect. A pharmaceutical composition having a P2X3 and/or P2X2/3 receptor antagonistic effect comprising a compoun

Reactivity of 4-Arylmethyl-3-chloro-6-methylpyridazines Towards Some Nucleophilic Reagents

4-Arylmethyl-3-chloro-6-methylpyridazines (1) react with aniline and hydrazine hydrate to give 3-anilino-(2a-c)- and 3-hydrazino-(2d-f)-pyridazine derivatives, respectively.Sodium azide reacts with 1 to give the tetrazolopyridazines (4).Condensation of (1a,b) with benzaldehyde yields only 4-arylmethyl-6-methylpyridazin-3(2H)-ones (6).

Base-catalysed Condensation of Aromatic Aldehydes with 4,5-Dihydro-6-methylpyridazin-3(2H)-one

4-Arylmethyl-6-methylpyridazin-3(2H)-ones (IIIa-d) have been prepared by the condensation of aromatic aldehydes with 4,5-dihydro-6-methylpyridazin-3(2H)-one (I) in basic media.Compounds IIIa-d react in the lactim form with POCl3 to give 4-arylmethyl-3-chloro-6-methylpyridazines (Va-d), while these react in the lactam form with dimethyl sulphate to give 4-arylmethyl-2,6-dimethylpyridazin-3(2H)-ones (VIa-d).Compound IIId reacts with ethyl bromoacetate in the presence of sodium ethoxide to give the ethyl ester (VIIa) which reacts with benzylamine and hydrazine hydrate togive the corresponding N-benzylamide (VIIc) and hydrazide (VIId).The ester (VIIa) is readily hydrolysed to the corresponding acid (VIIb).