74829-71-3

Basic information

• Product Name: 2-[2-(2-bromophenyl)ethyl]benzoic acid
• Synonyms: 2-[2-(2-bromophenyl)ethyl]benzoic acid
• CAS NO: 74829-71-3
• Molecular Weight: 305.171
• Mol File: 74829-71-3.mol

Chemical Properties

• CAS DataBase Reference: 2-[2-(2-bromophenyl)ethyl]benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-(2-bromophenyl)ethyl]benzoic acid(74829-71-3)
• EPA Substance Registry System: 2-[2-(2-bromophenyl)ethyl]benzoic acid(74829-71-3)

Safety Data

• Hazardous Substances Data: 74829-71-3(Hazardous Substances Data)

Upstream product

• 118-90-1 ortho-methylbenzoic acid 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 124-38-9 carbon dioxide 

Downstream Products

• 1210-35-1 10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-one 
• 380614-71-1 {2-[2-(2-bromo-phenyl)-ethyl]-phenyl}-pyrrolidin-1-yl-methanone 

Relevant articles and documents

Palladium-catalyzed intramolecular decarboxylative coupling of arene carboxylic acids/esters with aryl bromides

Give me a ring? An efficient approach has been developed for the intramolecular decarboxylative coupling of arene carboxylic acids/esters with aryl bromides catalyzed by palladium (see scheme). From a synthetic viewpoint, this method is highly attractive because the catalyst loading is low, the optimized reaction conditions are mild, and the substrate scope is broad. Copyright

An anion-induced regio- and chemoselective acylation and its application to the synthesis of an anticancer agent

Figure presented An efficient Grignard- and organolithium-induced regio- and chemoselective anionic acylation is reported. A number of tricyclic ketones are prepared in good to excellent yields via this method. This method is complementary to the Frieldel-Crafts acylation for electron-deficient substrates. A novel anisole-based Grignard reagent was developed to effect the cyclization of sterically hindered substrates. This novel reagent has been successfully applied to the synthesis of Sch 66336, a candidate for oncologic treatment.