135837-63-7

Basic information

• Product Name: FMOC-3,4-DEHYDRO-PRO-OH
• Synonyms: FMOC-PRO(3,4-DEHYDRO)-OH;FMOC-DELTA-PRO-OH;FMOC-3,4-DEHYDRO-L-PROLINE;FMOC-3,4-DEHYDRO-L-PRO-OH;FMOC-3,4-DEHYDRO-PROLINE;FMOC-3,4-DEHYDRO-PRO-OH;(S)-1-FLUORENYLMETHOXYCARBONYL-2,5-DIHYDROPYRROLE-2-CARBOXYLIC ACID;N-FMOC-3,4-DEHYDRO-L-PROLINE
• CAS NO: 135837-63-7
• Molecular Formula: C₂₀H₁₇NO₄
• Molecular Weight: 335.35
• Product Categories: Amino Acid Derivatives;Amino Acids
• Mol File: 135837-63-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 549.6±50.0 °C(Predicted)
• Appearance: /
• Density: 1.356±0.06 g/cm3(Predicted)
• Storage Temp.: -15°C
• PKA: 3?+-.0.20(Predicted)
• CAS DataBase Reference: FMOC-3,4-DEHYDRO-PRO-OH(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-3,4-DEHYDRO-PRO-OH(135837-63-7)
• EPA Substance Registry System: FMOC-3,4-DEHYDRO-PRO-OH(135837-63-7)

Safety Data

• WGK Germany: WGK 2 water endangering
• HazardClass: IRRITANT
• Hazardous Substances Data: 135837-63-7(Hazardous Substances Data)

Usage

Chemical Properties

White or off-white powder

Upstream product

• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 4043-88-3 3,4-dehydro-L-proline 
• 51154-06-4 (S)-2,5-dihydropyrrole-1,2-dicarboxylic acid 1-tert-butyl ester 
• 74844-93-2 N-BOC-3,4-didehydro-(S)-proline methyl ester 
• 83548-49-6 (2S,4S)-2-methyl 1-tert-butyl 4-iodopyrrolidine-1,2-dicarboxylate 
• 74844-91-0 1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 

Downstream Products

• 1440521-90-3 C₃₉H₆₄N₁₂O₈ 

Relevant articles and documents

Epoxide derivatives of pipecolic acid and proline are inhibitors of pipecolate oxidase

The cis-4,5-epoxide derivative of L-pipecolic acid (2S,4S,5R-epoxypipecolic acid, cis-3) was synthesized and found to serve as an excellent substrate for L-pipecolate oxidase (L-PO) and also to cause time-dependent, irreversible inactivation of the enzyme. Data are presented showing this compound is a mechanism-based inhibitor of L-PO, whereas 2S,3R,4S-epoxyproline acts as a reversible inhibitor.

Development of novel cyclic peptides as pro-apoptotic agents

Our recent finding that paclitaxel behaves as a peptidomimetic of the endogenous protein Nur77 inspired the design of two peptides (PEP1 and PEP2) reproducing the effects of paclitaxel on Bcl-2 and tubulin, proving the peptidomimetic nature of paclitaxel.