74873-33-9

Basic information

• Product Name: 2-Amino-6-methyl-4-p-tolyl-nicotinonitrile
• Synonyms: 2-Amino-6-methyl-4-p-tolyl-nicotinonitrile
• CAS NO: 74873-33-9
• Molecular Weight: 223.277
• Mol File: 74873-33-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-Amino-6-methyl-4-p-tolyl-nicotinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-6-methyl-4-p-tolyl-nicotinonitrile(74873-33-9)
• EPA Substance Registry System: 2-Amino-6-methyl-4-p-tolyl-nicotinonitrile(74873-33-9)

Safety Data

• Hazardous Substances Data: 74873-33-9(Hazardous Substances Data)

Upstream product

• 2826-25-7 2-(4-methylbenzylidene)malononitrile 
• 67-64-1 acetone 
• 104-87-0 4-methyl-benzaldehyde 
• 109-77-3 malononitrile 

Relevant articles and documents

Synthesis of a novel and reusable biological urea based acidic nanomagnetic catalyst: Application for the synthesis of 2-amino-3-cyano pyridines via cooperative vinylogous anomeric based oxidation

In the current study, a novel and reusable biological urea based nano magnetic catalyst namely Fe3O4@SiO2@(CH2)3-urea-benzimidazole sulfonic acid was designed and synthesized. The structure of the titled catalyst was fully characterized using several skills including Fourier transform infrared (FT-IR) spectroscopy, energy dispersive X-ray (EDX) analysis, X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermo gravimetric analysis/differential thermal analysis (TG/DTG) and vibrating sample magnetometer (VSM). Then, the catalytic performance of Fe3O4@SiO2@(CH2)3-urea-benzimidazole sulfonic acid was successfully inspected towards the multicomponent synthesis of 2-amino-3-cyano pyridine derivatives through a vinylogous anomeric based oxidation pathway.

Nanomagnetically modified vitamin B3 (Fe3O4@Niacin): An efficient and reusable green biocatalyst for microwave-assisted rapid synthesis of 2-amino-3-cyanopyridines in aqueous medium

Superparamagnetic nanoparticles of modified vitamin B3 (Fe3O4@Niacin) represent a new, efficient and green biocatalyst for the one-pot synthesis of 2-amino-3-cyanopyridine derivatives via four-component condensation reaction between aldehydes, ketones, malononitrile, and ammonium acetate under microwave irradiation in water. This new magnetic organocatalyst was easily isolated from the reaction mixture by magnetic decantation using an external magnet and reused at least six times without significant degradation in the activity. The catalyst was fully characterized by FT-IR, XRD, SEM, VSM, UV–Vis, DLS and EDS. Excellent yield, very short reaction time (7–10?min), operational simplicity, easy work-up procedure, avoidance of hazardous or toxic catalysts and organic solvents are the main advantages of this green methodology which makes it more economic than the other conventional methods.

A Simple Method for the Preparation of 2-Amino-4-aryl-3-cyanopyridines by the Condensation of Malononitrile with Aromatic Aldehydes and Alkyl Ketones in the Presence of Ammonium Acetate

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