748758-45-4 Usage
Uses
Used in Pharmaceutical Industry:
6-AMINO-N-CYCLOHEXYL-N,3-DIMETHYLTHIAZOLO[3,2-A]BENZIMIDAZOLE-2-CARBOXAMIDE HYDROCHLORIDE is used as a pharmaceutical agent for its selective antagonist activity. It acts as a noncompetitive, high affinity, and selective antagonist of metabotropic glutamate receptor type 1 (mGluR-1), which plays a crucial role in various neurological and psychiatric disorders. By targeting this receptor, YM 298198 Hydrochloride has the potential to modulate the activity of mGluR-1, offering therapeutic benefits in the treatment of conditions such as anxiety, depression, and neurodegenerative diseases.
Used in Research and Development:
In the field of research and development, 6-AMINO-N-CYCLOHEXYL-N,3-DIMETHYLTHIAZOLO[3,2-A]BENZIMIDAZOLE-2-CARBOXAMIDE HYDROCHLORIDE serves as a valuable tool for studying the function and role of mGluR-1 in cellular processes and disease mechanisms. Its selective antagonist properties allow researchers to investigate the receptor's involvement in various signaling pathways and its potential as a therapeutic target for developing novel drugs and treatments.
Used in Drug Design and Optimization:
The unique molecular structure of 6-AMINO-N-CYCLOHEXYL-N,3-DIMETHYLTHIAZOLO[3,2-A]BENZIMIDAZOLE-2-CARBOXAMIDE HYDROCHLORIDE makes it a useful starting point for drug design and optimization efforts. Researchers can leverage its selective antagonist activity against mGluR-1 to develop new compounds with improved potency, selectivity, and pharmacokinetic properties. This can lead to the creation of more effective and safer drugs for the treatment of neurological and psychiatric disorders.
Biological Activity
Non-competitive antagonist with high affinity and selectivity for mGlu 1 receptors (K i = 19 nM); inactive at other mGlu receptor subtypes (mGlu 2-7 ), ionotropic receptors and glutamate transporters (IC 50 > 10 μ M). Inhibits glutamate-induced IP production more potently than CPCCOEt (IC 50 values are 16 nM and 6.3 μ M respectively), and is orally active in vivo , demonstrating an antinociceptive effect in hyperalgesic mice.
Check Digit Verification of cas no
The CAS Registry Mumber 748758-45-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,4,8,7,5 and 8 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 748758-45:
(8*7)+(7*4)+(6*8)+(5*7)+(4*5)+(3*8)+(2*4)+(1*5)=224
224 % 10 = 4
So 748758-45-4 is a valid CAS Registry Number.
InChI:InChI=1/C18H22N4OS.ClH/c1-11-16(17(23)21(2)13-6-4-3-5-7-13)24-18-20-14-9-8-12(19)10-15(14)22(11)18;/h8-10,13H,3-7,19H2,1-2H3;1H
748758-45-4Relevant academic research and scientific papers
Pharmaceuticals for neurogenic pain
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Page/Page column 8-9, (2010/02/05)
This invention relates to pharmaceuticals for neuropathic pains comprising an mGluR1 receptor antagonist for systemic administration. Drugs efficacious in treating various neuropathic pain can be provided by the invention.
